4 documents found, page 1 of 1
Plasmatic Oxidative and Metabonomic Profile of Patients with Different Degrees ...
Silva-Vaz, Pedro; Jarak, Ivana; Rato, Luis; Oliveira, Pedro F.; Morgado-Nunes, Sara; Paulino, Aida; Castelo-Branco, Miguel; Botelho, FilomenaAcute pancreatitis (AP) is an inflammatory process of the pancreas with variable involvement of the pancreatic and peripancreatic tissues and remote organ systems. The main goal of this study was to evaluate the inflammatory biomarkers, oxidative stress (OS), and plasma metabolome of patients with different degrees of biliary AP severity to improve its prognosis. Twenty-nine patients with biliary AP and 11 heal...
Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applic...
Silva-Vaz, Pedro; Abrantes, Ana Margarida; Castelo-Branco, Miguel; Gouveia, António; Botelho, Maria Filomena; Tralhão, José GuilhermeAcute pancreatitis (AP) is a severe inflammation of the pancreas presented with sudden onset and severe abdominal pain with a high morbidity and mortality rate, if accompanied by severe local and systemic complications. Numerous studies have been published about the pathogenesis of AP; however, the precise mechanism behind this pathology remains unclear. Extensive research conducted over the last decades has de...
Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis
Silva-Vaz, Pedro; Abrantes, Ana Margarida; Morgado-Nunes, Sara; Castelo-Branco, Miguel; Gouveia, António; Botelho, Maria FilomenaAcute pancreatitis (AP) is an inflammatory disorder of the pancreas that, when classified as severe, is associated with high morbidity and mortality. Promptly identifying the severity of AP is of extreme importance for improving clinical outcomes. The aim of this study was to compare the prognostic value of serological biomarkers, ratios, and multifactorial scores in patients with acute biliary pancreatitis and...
Murine Models of Acute Pancreatitis: A Critical Appraisal of Clinical Relevance
Silva-Vaz, Pedro; Abrantes, Ana Margarida; Gouveia, António; Botelho, Maria Filomena; Tralhão, José Guilherme; Castelo-Branco, MiguelAcute pancreatitis (AP) is a severe disease associated with high morbidity and mortality. Clinical studies can provide some data concerning the etiology, pathophysiology, and outcomes of this disease. However, the study of early events and new targeted therapies cannot be performed on humans due to ethical reasons. Experimental murine models can be used in the understanding of the pancreatic inflammation, becau...