This study aimed to evaluate the anti-leishmania activity of extracts and fractions from stem and leaf of Montrichardia linifera against Leishmania amazonensis. The stem (EES) and leaf (EEL) extracts were obtained by maceration of powders with 96º GL alcohol. The extracts were subjected to exhaustive extraction using a reflux system and solvents of increasing polarity, obtaining 4 fractions for each extract: he...
Drug treatment for leishmaniasis can lead to several adverse reactions, and therapy-resistant isolates of Leishmania have already been found. In this scenario, the search for therapeutic alternatives and alkaloids, isolated from plants belonging to the genus Aspidosperma, has proved to be promising as antiparasitic. The present study evaluated the antipromastigote, amastigote and cytotoxicity activity of the ex...
FAPESP (2012/08338-8; 14/50315-0).; Universidade de S?o Paulo. Faculdade de Medicina. Departamento de Patologia. S?o Paulo, SP, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Universidade de S?o Paulo. Faculdade de Medicina. Departamento de Patologia. S?o Paulo, SP, Brazil.; Universidade de S?o Paulo. Faculdade de Medicina. Departamento de Pat...
University of Cambridge School of Clinical Medicine. Wellcome Trust/MRC Building. Cambridge Institute for Medical Research. Addenbrookes Hospital. Cambridge , UK.; University of Cambridge School of Clinical Medicine. Wellcome Trust/MRC Building. Cambridge Institute for Medical Research. Addenbrookes Hospital. Cambridge , UK.; University of Cambridge School of Clinical Medicine. Wellcome Trust/MRC Building. Camb...
This study was supported by the Sao Paulo Research Foundation (FAPESP) grants #2014/50315-0, #2015/01154-7, #2017/24834-9, #2018/04698-6 and GVAF and CMSP Scholarship from CAPES (Social Demand) and Laborat?rio de Patologia de Mol?stias Infecciosas (LIM50 HC-FMUSP). MDL is a research fellow from the National Research Council-CNPq, Brazil, grant #302174/2017-6.; Universidade de S?o Paulo. Faculdade de Medicina. D...
This research was financially supported by the Instituto Evandro Chagas (Brazilian Ministry of Health) and by the N?cleo de Medicina Tropical (Universidade Federal do Par?, Brasil). Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (editals no.1/2017- PIBIC/IEC/CNPq 2017-2018 and no.1/2016-PIBIC/IEC/CNPq 2016-2017); Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. An...
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua,...
Cambridge Institute for Medical Research. Wellcome Trust Centre for Molecular Mechanisms in Disease. Cambridge, United Kingdom / University of Cambridge Clinical School. Addenbrooke?s Hospital. Cambridge, United Kingdom.; Princess Anne Hospital. Human Genetics Centre. Southampton, United Kingdom.; University of Leeds. School of Biology. Leeds, United Kingdom.; Minist?rio da Sa?de. Funda??o Nacional de Sa?de. In...
This work was supported by Instituto Evandro Chagas (Secretaria de Vigil?ncia em Sa?de, Minist?rio da Sa?de, Brazil); N?cleo de Medicina Tropical (Universidade Federal do Par?, Brazil); Laborat?rio de Investiga??o M?dica (LIM)-50 (Hospital de Cl?nicasFaculdade de Medicina-Universidade de S?o Paulo (USP), Brazil) and, Funda??o de Amparo a Pesquisa do Estado de S?o Paulo (FAPESP: 2014/50315-0).; Minist?rio da Sa?...