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The usefulness of an Online Simplified Screening Questionnaire (SSQ) in identif...
Vazquez, Fabiana L.; Silveira, Henrique C. S.; Otero, Ubirani B.; Hosokawa, Thais T.; Fregnani, José Humberto T. G.; Longatto, Adhemar; Reis, R. M.To obtain a history of occupational exposure in the workplace, the questionnaire is one of the main sources of information. The aim of this study was to develop an online questionnaire using the REDCap data management platform based on the Work-Related Cancer Surveillance Guidelines, reported by the Brazilian National Cancer Institute. Several issues were taken into consideration for its routine application. It...
MicroRNA profiling in human breast cancer cell lines exposed to the anti-neopla...
Bordinhão, A. L. R.; Evangelista, Adriane F.; Oliveira, R. J. S.; Macedo, Taciane; Silveira, Henrique C. S.; Reis, R. M.; Marques, Marcia M. C.Cediranib, a pan-tyrosine kinase inhibitor is showing promising results for the treatment of several solid tumours. In breast cancer, its effects remain unclear, and there are no predictive biomarkers. Several studies have examined the expression profiles of microRNAs (miRNAs) in response to different chemotherapy treatments and found that the expression patterns may be associated with the treatment response. T...
MicroRNA expression as risk biomarker of breast cancer metastasis : a pilot ret...
Marino, Augusto L. F.; Evangelista, Adriane F.; Vieira, René A. C.; Macedo, Taciane; Kerr, Ligia M.; Machado, Lucas Faria AbrahãoBackground: MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in post-transcriptional gene regulation and have recently been shown to play a role in cancer metastasis. In solid tumors, especially breast cancer, alterations in miRNA expression contribute to cancer pathogenesis, including metastasis. Considering the emerging role of miRNAs in metastasis, the identification of predictive markers is n...
Emissions generated by sugarcane burning promote genotoxicity in rural workers:...
Silveira, Henrique C. S.; Carrijo, Marina Schmidt; Seidel, Ervald Henrique; Neto, Cristovam Scapulatempo; Longatto Filho, Adhemar; Carvalho, André LopesBackground: To determine the possible genotoxic effect of exposure to the smoke generated by biomass burning on workers involved in manual sugar cane harvesting. Methods: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of adminis...