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A machine learning approach for single cell interphase cell cycle staging

Narotamo, H; Fernandes, MS; Moreira, AM; Melo, S; Seruca, R; Silveira, M; Sanches, JM

The cell nucleus is a tightly regulated organelle and its architectural structure is dynamically orchestrated to maintain normal cell function. Indeed, fluctuations in nuclear size and shape are known to occur during the cell cycle and alterations in nuclear morphology are also hallmarks of many diseases including cancer. Regrettably, automated reliable tools for cell cycle staging at single cell level using in...




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