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Recent developments and challenges in the application of fungal laccase for the...
Magalhães, Flávia F.; Pereira, Ana F. S.; Cristóvão, Raquel O.; Barros, Rita A. M.; Faria, Joaquim L.; Silva, Cláudia G.; Freire, Mara G.According to the European Environment Agency, the textile industry is responsible for 20% of global water pollution due to dyeing and finishing products, thus facing severe environmental challenges. It is essential to design more biocompatible and sustainable treatment processes capable of removing dyes from industrial wastewater to fight this environmental hazard. Chemical industries must change traditional ch...
Expansion of targeted drug-delivery systems using microbially sources biosurfac...
Nunes, João C. F.; Magalhães, Flávia F.; Araújo, Marília T.; Almeida, Mafalda R.; Freire, Mara G.; Tavares, Ana P. M.Microbial biosurfactants have been emerging as promising compounds for drug-delivery systems (DDS) advances. They can be formed using diverse classes of microorganisms, being versatile biocompounds with specific surface characteristics. When compared to chemical surfactants, good biodegradability, small toxicity, and potential biological activity are the key advantages of biosurfactants. Moreover, these compoun...
Biocatalysis in biphasic systems based on ionic liquids
Baptista, Inês O.; Ferreira, Ana M.; Magalhães, Flávia F.; Freire, Mara G.; Tavares, Ana P. M.; Coutinho, João A. P.Biocatalytic processes find increasing applications in industry due to the high efficiency of biotransformations, and renewable nature of the enzymes and substrates. Enzymatic biocatalysis is an attractive alternative to conventional chemical catalysis, with corresponding advances now allowing a wide range of biotransformations. However, to make the enzymatic process sustainable, it is essential to separate the...
New liquid supports in the development of integrated platforms for the reuse of...
Magalhães, Flávia F.; Pereira, Ana F.; Freire, Mara G.; Tavares, Ana P. M.Polydopamine (PDA), a bioinspired polymer from mussel adhesive proteins, has attracted impressive attention as a novel coating for (nano) materials with an adequate conformal layer and adjustable thickness. Currently, PDA is obtained from dopamine chemical oxidation under alkaline conditions, limiting its use in materials sensible to alkaline environments. Envisaging a widespread use of PDA, the polymerization ...
Tailoring the partitioning of proteins using ionic liquids as adjuvants in poly...
Magalhães, Flávia F.; Pereira, Matheus M.; Sousa, Rita de Cássia Superbi de; Tavares, Ana P. M.; Coutinho, João A. P.; Freire, Mara G.Aqueous biphasic systems (ABS) are promising for proteins purification; however, when dealing with samples comprising several proteins, the selectivity towards a target protein is difficult to achieve. In this work, the addition of ionic liquids (ILs) as adjuvants (5 and 10 wt%) in ABS composed of polyethyleneglycol (PEG) and Dextran was investigated to tailor proteins’ partitioning between the coexisting phase...
Advances in aqueous biphasic systems for biotechnology applications
Magalhães, Flávia F.; Tavares, Ana P. M.; Freire, Mara G.Amongst the several processes investigated in the Biotechnology field, aqueous biphasic systems (ABSs) have been a target of relevant research, particularly in the downstream processing of high-value compounds of biological nature and, more recently, in emerging applications such as in the development of artificial cells and synthetic biology, micropatterning and 3D printing, and sample pretreatment and diagnos...
Anti-cancer biosurfactants
Magalhães, Flávia F.; Nunes, João C. F.; Araújo, Marília T.; Ferreira, Ana M.; Almeida, Mafalda R.; Freire, Mara G.; Tavares, Ana P. M.Microbial biosurfactants are amphiphilic compounds and surface-active biomolecules produced by several microorganisms. Recently, biosurfactants have emerged as promising agents for cancer therapy since a high diversity of these molecules has shown the ability to induce cytotoxicity against many cancer cell lines, thus regulating cancer progression processes. In this sense, microbial biosurfactants are a potenti...
Recent applications of ionic liquids in biocatalysis
Magalhães, Flávia F.; Valente, Ana I.; Tavares, Ana Paula M.; Freire, Mara G.The use of biocatalysts has become a real and competitive alternative to traditional chemical catalysts, contributing to the design of more environmentally friendly processes. However, depending on the enzymatic reaction mechanism, and particularly in nonaqueous reactions, the extensive use of organic solvents is required, which results in some drawbacks, such as low biocatalyst activity, loss of solvents to th...
Recovery of immunoglobulin G from rabbit serum using κ-carrageenan-modified hyb...
Magalhães, Flávia F.; Almeida, Mafalda R.; Soares, Sofia F.; Trindade, Tito; Freire, Mara G.; Daniel-da-Silva, Ana Luísa; Tavares, Ana P. M.Immunoglobulin G (IgG) has been used in the treatment of cancer, autoimmune diseases and neurological disorders, however, the current technologies to purify and recover IgG from biological media are of high-cost and time-consuming, resulting in high-cost products. In this sense, the search for cost-effective technologies to obtain highly pure and active IgG is highly required. The present work proposes a simple...
Recovery of immunoglobulin G from rabbit serum using k-carrageenan-modified hyb...
Magalhães, Flávia F.; Almeida, Mafalda R.; Soares, Sofia F.; Trindade, Tito; Freire, Mara G.; Daniel-da-Silva, Ana Luísa; Tavares, Ana P. M.Immunoglobulin G (IgG) has been used in the treatment of cancer, autoimmune diseases and neurological disorders, however, the current technologies to purify and recover IgG from biological media are of high-cost and time-consuming, resulting in high-cost products. In this sense, the search for cost-effective technologies to obtain highly pure and active IgG is highly required. The present work proposes a simple...