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Património e paisagem: gestão, análise, projeto
Ferreira, Teresa C.; Marques, Teresa P.; Botelho, Maria Leonor; Romão, Xavier; Póvoas, Rui FernandesThe training unit "Heritage and Landscape. Management, Analysis, Design" proposes to foster interdisciplinary work areas - between Architecture, Art History, Landscape Architecture and Civil Engineering - essential for an understanding of the concept of heritage in its contemporary and extended sense (built and natural, material and immaterial) a driver for the sustainable development of cities, landscapes and ...
Micronuclei formation upon radioiodine therapy for well-differentiated thyroid ...
Santos, Luís S.; Gil, Octávia M.; Silva, Susana N.; Gomes, Bruno C.; Ferreira, Teresa C.; Limbert, Edward; Rueff, JoséRadioiodine therapy with131I remains the mainstay of standard treatment for well-differentiated thyroid cancer (DTC). Prognosis is good but concern exists that131I-emitted ionizing radiation may induce double-strand breaks in extra-thyroidal tissues, increasing the risk of secondary malignancies. We, therefore, sought to evaluate the induction and 2-year persistence of micronuclei (MN) in lymphocytes from 26131...
A proactive approach to the conservation of historic and cultural Heritage: The...
Morais, Maria José; Masciotta, Maria Giovanna; Ramos, Luís F.; Oliveira, Daniel V.; Azenha, Miguel; Pereira, E. N. B.; Lourenço, Paulo B.Presently, no systematic policy for the preventive conservation of the built cultural heritage exists in South-West Europe. Current approaches for inspection, diagnosis, monitoring and reactive conservation are normally intermittent, unplanned, expensive and lack methodical strategy. The available financial resources are scarce and are mostly addressed to listed buildings. Besides, owners and stakeholders often...
Thyroid cancer: the quest for genetic susceptibility involving DNA repair genes
Santos, Luís S.; Gomes, Bruno Costa; Bastos, Hélder N.; Gil, Octávia M.; Azevedo, Ana Paula; Ferreira, Teresa C.; Limbert, Edward; Silva, Susana N.The incidence of thyroid cancer (TC), particularly well-differentiated forms (DTC), has been rising and remains the highest among endocrine malignancies. Although ionizing radiation (IR) is well established on DTC aetiology, other environmental and genetic factors may also be involved. DNA repair single nucleotide polymorphisms (SNPs) could be among the former, helping in explaining the high incidence. To furth...
Mismatch repair single nucleotide polymorphisms and thyroid cancer susceptibility
Santos, Luís S.; Silva, Susana N.; Gil, Octávia M.; Ferreira, Teresa C.; Limbert, Edward; Rueff, JoséThyroid cancer (TC) is the most common endocrine malignancy and its incidence continues to rise worldwide. Ionizing radiation exposure is the best established etiological factor. Heritability is high; however, despite valuable contribution from recent genome-wide association studies, the current understanding of genetic susceptibility to TC remains limited. Several studies suggest that altered function or expre...
Assessment of iodine-131 in the urine of the patient’s family members after dif...
Raminhas Carapinha, Maria João; Costa, Gracinda; Ferreira, Teresa C.; Salgado, Lucília; Carvalho, Inês; Sofia, Monica; Isidoro, Jorge; Rézio, TeresaIntroduction - The aim is to evaluate the internal exposure of the family members (FMs) of the patients (PATs) undergoing iodine-131 (131I) thyroid cancer (TC) therapy and quantify the amount of 131I in the FMs, excreted through the urinary. Methods - An observational study with convenience sampling was performed, including 25 PATs and 34 FMs. The PATs, who underwent 131I treatments for TC, were discharged from...
131I therapy in thyroid cancer and benign thyroid diseases: personal dose equiv...
Raminhas Carapinha, Maria João; Costa, Gracinda; Ferreira, Teresa C.; Salgado, Lucília; Vaz, Sofia; Ferreira, Rui; Isidoro, Jorge; Rézio, TeresaIntroduction - The aim is to quantify the personal dose equivalent HP(10) in the family members (FMs) of the patients (PATs) undergoing iodine-131 thyroid cancer (TC) therapy and benign thyroid diseases (BTD) and to compare the HP(10) values of children and adults. Methods - An observational study with convenience sampling was performed, including 83 FMs (59% ♂) of 48 PATs (72.9% ♀). All FMs wore a whole body T...
Polymorphisms in base excision repair genes and thyroid cancer risk
Santos, Luís S.; Branco, Sandra C.; Silva, Susana N.; Azevedo, Ana Paula; Gil, Octávia M.; Manita, Isabel; Ferreira, Teresa C.; Limbert, EdwardThyroid cancer (TC) is the most frequent endocrine malignancy, accounting however for only 1-2% of all human cancers, and the best-established risk factor for TC is radiation exposure, particularly during childhood. Since the BER pathway seems to play an important role in the repair of DNA damage induced by IR and other genotoxicants, we carried out a hospital-based case-control study in order to evaluate the p...