2 documents found, page 1 of 1
Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs): an intrigui...
Silveira,Mariana Ribeiro Marcondes da; Andrade,Joaquina; Garzon,ElianaSIRPIDs, an acronym for stimulus-induced rhythmic, periodic, or ictal discharges, were first named in 2004. This is a pattern observed in continuous electroencephalogram (CEEG) consistently elicited by stimulation in comatose patients. The pathophysiology of SIRPIDs probably involves dysregulation of subcortico–cortical projections, particularly thalamocortical circuit, in a markedly abnormal brain with hyperex...
Effectiveness of clobazam as add-on therapy in children with refractory focal e...
Silveira,Mariana Ribeiro Marcondes da; Montenegro,Maria Augusta; Franzon,Renata Cristina; Guerreiro,Carlos A.M.; Guerreiro,Marilisa M.The objective of this study was to evaluate the safety and efficacy of clobazam in children with refractory focal epilepsy. We investigated 100 consecutive patients concerning etiology of epilepsy, previously used antiepileptic drugs, seizure frequency and adverse events. Clobazam was introduced as add-on therapy in patients with previous failure of at least two monotherapies. Mean age was eight years-old and 3...