3 documents found, page 1 of 1
Glial-restricted precursors stimulate endogenous cytogenesis and effectively re...
Martins-Macedo, Joana; Araújo, Bruna; Anjo, Sandra I.; Silveira-Rosa, Tiago; Patrício, Patrícia; Alves, Nuno Dinis; Silva, Joana M.; Teixeira, Fábio G.Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and dise...
StressMatic: a novel automated system to induce depressive- and anxiety-like ph...
Martins-Macedo, Joana; Mateus-Pinheiro, António; Alves, Cátia; Veloso, Fernando José Silva; Gomes, Eduardo D.; Ribeiro, Inês; Correia, Joana S.Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, ...
Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes a...
Loureiro-Campos, Eduardo; Mateus-Pinheiro, António; Patrício, Patrícia; Cunha, Carina Isabel Soares; Silva, Joana; Sardinha, Vanessa Alexandra MoraisThe transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neurogenic, behavioral, and functional impact of a constitutive and heterozygous AP2γ deletion in mice from early post...