4 documents found, page 1 of 1
Taxifolin and Lucidin as Potential E6 Protein Inhibitors
Gomes, Diana; Yaduvanshi, Shivani; Silvestre, Samuel; Duarte, Ana Paula; Santos, Adriana O.; Soares, Christiane P.; Kumar, Veerendra; Passarinha, LuísThis work was supported by the Foundation for Science and Technology (FCT), through funds from the State Budget, and by the European Regional Development Fund through the “Pro-grama Operacional Regional do Centro (Centro 2020)—Sistema de Apoio à Investigação Científica e Tecnológica—Programas Integrados de IC&DT” (Project Centro-01-0145-FEDER-000019—C4—Centro de Competências em Cloud Computing). project LA/P/01...
Recent developments in new therapeutic agents against alzheimer and parkinson d...
Cruz-Vicente, Pedro; Passarinha, Luís A.; Silvestre, Samuel; Gallardo, EugeniaNeurodegenerative diseases (ND), including Alzheimer’s (AD) and Parkinson’s Disease (PD), are becoming increasingly more common and are recognized as a social problem in modern societies. These disorders are characterized by a progressive neurodegeneration and are considered one of the main causes of disability and mortality worldwide. Currently, there is no existing cure for AD nor PD and the clinically used d...
In silico approaches
Gomes, Diana; Silvestre, Samuel; Duarte, Ana Paula; Venuti, Aldo; Soares, Christiane P.; Passarinha, Luís; Sousa, ÂngelaProject Centro-01-0145-FEDER-000019—C4 LA/P/0140/2020; Cervical cancer (CC) is the fourth most common pathology in women worldwide and presents a high impact in developing countries due to limited financial resources as well as difficulties in monitoring and access to health services. Human papillomavirus (HPV) is the leading cause of CC, and despite the approval of prophylactic vaccines, there is no effective ...
Discovery of Small Molecules as Membrane-Bound Catechol-O-methyltransferase Inh...
Cruz-Vicente, Pedro; Gonçalves, Ana M.; Ferreira, Octávio; Queiroz, João A.; Silvestre, Samuel; Passarinha, Luís A.; Gallardo, EugéniaAssociate Laboratory Institute for Health and Bioeconomy—i4HB (project LA/P/0140/2020), which are financed by national funds from FCT/MCTES. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.; A pharmacophore-based virtual screening methodology was used to discover new catecholO-methyltransferase (COMT) inhibitors with interest in Parkinson’s disease therapy. To do so, pharmacophore models were construct...