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pH-sensitive nanoliposomes for passive and CXCR-4-mediated marine yessotoxin de...
Vieira, Ana M. G.; Silvestre, Oscar F.; Silva, Bruno F. B.; Ferreira, Celso J. O.; Lopes, Ivo Edgar Araújo; Gomes, Andreia C; Espiña, BegoñaBackground: Yessotoxin (YTX), a marine-derived drug, was encapsulated in PEGylated pH-sensitive nanoliposomes, covalently functionalized (strategy I) with SDF-1α and by nonspecific adsorption (strategy II), to actively target chemokine receptor CXCR-4. Methods: Cytotoxicity to normal human epithelial cells (HK-2) and prostate (PC-3) and breast (MCF-7) adenocarcinoma models, with different expression levels of C...
Data: 2022
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Origem: RepositóriUM - Universidade do Minho