Encontrados 4 documentos, a visualizar página 1 de 1
Analysis of financial sustainability to guarantee full access to cancer drugs
Rocha Filho, José de Arimatea; Matta, Carolina Barbosa Brito da; Silva, Thiago Douberin da; Paz Neta, Doralice Conceição daThe high incidence of cancer cases has made it an evident public health problem worldwide. Public network managers in Brazil claim that the funds transferred are not sufficient to cover the costs of chemotherapy. This work provided an overview of the service offered by the SUS in the oncology care network in Pernambuco and evaluated the financial sustainability to ensure access to chemotherapy drugs in a refere...
Ability of two new thiazolidinediones to downregulate proinflammatory cytokines...
Rêgo, Moacyr Jesus Barreto de Melo; Azoubel-Antunes, Adriana; Bezerra, Mariana Brayner-Cavalcanti Freire; Pereira, Michelly CristinyAllergic asthma is a chronic, complex inflammatory disease of the airway. Despite extensive studies on the immunomodulation of T helper (Th) cell pathways (i.e., Th1 and Th2) in asthma, little is known about the effects of Th17 pathway modulation, particularly that involving peroxisome proliferator-activated receptors (PPARs). In response, two new thiazolidinedione derivatives—namely, LPSF–GQ-147 and LPSF–CR-35...
Synthesis and biological evaluation of novel imidazolidine derivatives as candi...
Matos-Rocha, Thiago José; Lima, Maria do Carmo Alves de; Silva, Anekécia Lauro da; Oliveira, Jamerson Ferreira de; Gouveia, Allana Lemos AndradeIntroduction: Schistosomiasis is an infectious parasitic disease caused by trematodes of the genus Schistosoma, which threatens at least 258 million people worldwide and its control is dependent on a single drug, praziquantel. The aim of this study was to evaluate the anti-Schistosoma mansoni activity in vitro of novel imidazolidine derivatives. Material and methods: We synthesized two novel imidazolidine deriv...
Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythemat...
Silva, Juliana Cruz da; Mariz, Henrique Ataide; Rocha Júnior, Laurindo Ferreira da; Oliveira, Priscilla Stela Santana de; Dantas, Andrea TavaresOBJECTIVES: Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. The purpose of this study was to evaluate the immunomodulatory activity of hydroxychloroquine in T helper 17 (Th17) cytokines in hea...