Background: Severe periodontitis is considered the sixth most prevalent disease worldwide [1]. It is a chronic inflammatory condition affecting the tooth-supporting structures due to genetic, environmental, and microbial factors [2]. The host immune response partially contributes to the magnitude of the inflammatory process. Furthermore, this process involves a diversity of immunomediators that initiate and sus...
A interdependência económica pode aprofundar relações económicas quando existem ganhos recíprocos. No entanto, uma assimetria na interdependência causa problemas para a defesa dos Estados, criando um dilema de segurança e o assumir de posições de realismo ofensivo ou defensivo. Este dilema, normalmente inserido na perspetiva de integridade territorial e soberania também se aplica no quadro das relações internac...
Russia has been credibly accused of trying to weaken Western liberal democracies with use of digital means. Cybersecurity experts, intelligence agencies, investigative journalists, and government services, have detailed the Kremlin's actions in illegally accessing digital infrastructures, disseminating stolen contents online, and influencing political debate on digital platforms to create dissention and polariz...
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This study reports the formulation and delivery of hyaluronic acid-Zein (HA-Zein) nanogels loaded with Shikonin (SK) to selectively attenuate macrophage inflammasome. The self-assembled nanogels, produced by nanoprecipitation, exhibited high encapsulation efficiency, and were selectively internalized by human THP-1-derived macrophages without eliciting cytotoxic responses. Cell treatment with HA-Zein-SK nanogel...
Circulating phagocytic cells often serve as cellular targets for a large number of pathogens such as <i>Leishmania</i> parasites. Studying primary human cells in an infectious context requires lengthy procedures for cell isolation that may affect the analysis performed. Using whole blood and a no-lyse and no-wash flow cytometric assay (<i>NoNo</i> assay), we monitored the <i>Leishmania infantum</i> infection of...
A interdependência económica pode aprofundar relações económicas quando existem ganhos recíprocos. No entanto, uma assimetria na interdependência causa problemas para a defesa dos Estados, criando um dilema de segurança e o assumir de posições de realismo ofensivo ou defensivo. Este dilema, normalmente inserido na perspetiva de integridade territorial e soberania também se aplica no quadro das relações internac...
Pode a democracia sobreviver à internet é uma pergunta vital. Está o debate político online a deteriorar o processo democrático, com o aumento do extremismo e polarização? Democracias liberais assentam em liberdades como a de expressão. O usufruto desta é condição para outras formas de liberdade, e é crucial para uma sociedade informada e participativa em processos de deliberação política. Sempre existiram cond...
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Prediction parameters of possible outcomes of canine leishmaniasis (CanL) therapy might help with therapeutic decisions and animal health care. Here, we aimed to develop a diagnostic method with predictive value by analyzing two groups of dogs with CanL, those that exhibited a decrease in parasite load upon antiparasitic treatment (group: responders) and those that maintained high parasite load despite the trea...