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Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and r...
Liberto, Natália Aparecida; Simões, Juliana Baptista; Silva, Sarah de Paiva; Fernandes, Sergio Antonio; Silva, Cristiane Jovelina daAn efficient method for the synthesis of quinolines using microwave irradiation was developed providing 28 quinolines with good yields. The reaction procedures are environmentally friendly, convenient, mild and of easy work-up. Quinolines were evaluated for their antifungal, anticancer and antioxidant properties and exhibited high activities in all tests performed.
β-Cyclodextrin-assisted synthesis of Biginelli adducts under solvent-free condi...
Liberto, Natália Aparecida; Silva, Sarah de Paiva; Fátima, Ângelo de; Fernandes, Sergio AntonioA simple, green and efficient protocol was developed using b -cyclodextrin as a solid catalyst for the solvent-free synthesis of various Biginelli adducts. The advantages of our protocol included the following: (i) a metal-free methodology; (ii) high yields; (iii) simple and efficient work-up procedures; (iv) improved results under solvent-free conditions. b -cyclodextrin-catalyzed the Biginelli reactions for v...
Síntese do avenaciolídeo e novos análogos aromáticos e sua atividade frente a f...
Liberto, Natália AparecidaFundação de Amparo a Pesquisa do Estado de Minas Gerais; Avenaciolide, (1R,5R,6R)-4-methylidene-6-octil-2,7- dioxabicyclo[3.3.0]-octan-3,8-dione, is a natural bis-γ-lactone isolated from cultures of A. avenaceus and possess antifungal activity. This dissertation describes the synthesis of avenaciolide and new synthetic analogues (1R,5R,6R)-6-(2- arylethyl)-4-methylidene-2,7- dioxabicyclo[3.3.0]octan-3,8-di...