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Occult hepatitis C infection identified in injection drug users with direct ant...
Silva, Eliane; Marques, Sara; Leal, Bárbara; Canhão, Bernardo; Madaleno, João; Simão, Adélia; Carvalho, ArmandoBackground: Occult hepatitis C infection (OCI) is characterized by the detection of hepatitis C virus (HCV) RNA in hepatocytes and in peripheral blood mononuclear cells (PBMCs) without detection in serum. We aimed to evaluate OCI in drug and no drug users who achieved sustained virological response (SVR) after therapy with direct-acting antivirals (DAAs) and with HCV spontaneous resolution. Methods: Twenty-four...
Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung D...
Matos, Andreia Carvalho de; Macedo, Cristiane Pais; Mendes, Patrícia Afonso; Cipriano, Maria Augusta; Paiva, Artur; Simão, AdéliaAntibiotics are known to cause adverse reactions, but multiple organ involvement associated with nonspecific symptoms can lead to a delay in diagnosis. A definitive correlation between each toxin and its effects is difficult to establish due to concomitant potential toxins in the circulation. This article highlights an uncommon case of concomitant nitrofurantoin- induced autoimmune hepatitis and lung fibrosis t...
Perfusion Magnetic Resonance as a Biomarker for Sorafenib-Treated Advanced Hepa...
Campos, Marta; Candelária, Isabel; Papanikolaou, Nickolas; Simão, Adélia; Ferreira, Carlos; Manikis, Georgios C.; Alves, Filipe CaseiroBackground: Sorafenib is the currently recommended therapy in patients with advanced hepatocellular carcinoma (HCC). Among the several biomarkers available for the evaluation of the therapeutic response and prognosis, there is perfusion magnetic resonance imaging (p-MRI) that, through measurement of the vascular permeability unit (ktrans), may retrieve useful information regarding the microvascular properties o...
Advanced Stage Hepatocellular Carcinoma with Multiple Metastasis and Vascular T...
Simão, Adélia; Silva, Raquel; Correia, Lurdes; Alves, Filipe Caseiro; Carvalho, Armando; Costa, J. M. NascimentoSorafenib is a multi-targeted tyrosine kinase inhibitor, with antiangiogenic and antiproliferative properties, approved for the treatment of advanced hepatocellular carcinoma. It induces a significant increase in the median overall survival, despite a complete response to treatment being rare. We report a clinical case of a 60-year-old male with hepatic cirrhosis, Child-Pugh class A and performance status 0, an...
Advanced Stage Hepatocellular Carcinoma with Multiple Metastasis and Vascular T...
Simão, Adélia; Silva, Raquel; Correia, Lurdes; Alves, Filipe Caseiro; Carvalho, Armando; Costa, J. M. NascimentoSorafenib is a multi-targeted tyrosine kinase inhibitor, with antiangiogenic and antiproliferative properties, approved for the treatment of advanced hepatocellular carcinoma. It induces a significant increase in the median overall survival, despite a complete response to treatment being rare. We report a clinical case of a 60-year-old male with hepatic cirrhosis, Child-Pugh class A and performance status 0, an...
Metalose: Causa Rara de Anemia Hemolítica Autoimune
Duarte, Joana; Correia, Lurdes; Simão, Adélia; Figueiredo, António; Carvalho, ArmandoIntrodução: A anemia hemolítica pode estar associada a múltiplas etiologias, nomeadamente a tóxicos, como os metais, sendo esta uma causa rara. Caso Clínico: Homem de 55 anos de idade, sujeito a artroplastia total da anca direita (prótese não cimentada com articulação cerâmica-cerâmica, cujo componente acetabular era constituído por uma cúpula metálica composta por uma liga de titânio, vanádio e alumínio na qua...
Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis...
Simão, Adélia; Madaleno, João; Silva, Nuno; Rodrigues, Fernando; Caseiro, Paula; Costa, José Nascimento; Carvalho, ArmandoBackground: Implementation of surveillance programs for at-risk populations and identification of biomarkers for early hepatocellular carcinoma (HCC) detection are a major public health goal. Recently, osteopontin (OPN) has attracted attention as a promising biomarker, with some potential advantages compared to alpha-fetoprotein (AFP), but its role in the context of alcoholic cirrhosis has never been assessed. ...
Carcinoma hepatocelular : estudo clínico, caracterização bioquímica e marcadore...
Simão, AdéliaTese de doutoramento em Ciências da Saúde (Pré-Bolonha), ramo de Medicina, especialidade de Medicina Interna (Medicina Interna), apresentada à Faculdade de Medicina da Universidade de Coimbra; Tese de doutoramento em Ciências da Saúde (Pré-Bolonha), ramo de Medicina, especialidade de Medicina Interna (Medicina Interna), apresentada à Faculdade de Medicina da Universidade de Coimbra; Introdução e objectivos Na E...
Metallosis: A Rare Cause of Autoimmune Hemolytic Anemia
Duarte, Joana; Correia, Lurdes; Simão, Adélia; Figueiredo, António; Carvalho, ArmandoIntroduction: Hemolytic anemia may be associated with multiple etiologies, including toxic substances, such as metals, which is a rare cause.Case Study: 55-year-old male, who underwent a total arthroplasty of the right hip (uncemented prostheses with ceramic-ceramic articulation with an acetabular component consisting of a dome composed of an alloy of titanium, aluminum and vanadium into which fitted a ceramic ...
Severe hyponatremia in older patients at admission in an internal medicine depa...
Correia, Lurdes; Ferreira, Rogério; Correia, Inês; Lebre, Ana; Carda, José; Monteiro, Rita; Simão, Adélia; Carvalho, Armando; Costa, NascimentoHyponatremia is common in older people, most often of multifactorial origin, and can be associated with poor clinical outcomes. The aim was to analyze the frequency of severe hyponatremia (sodium concentration below 125 mmol/L), risk factors and mortality association in hospitalized older patients. A retrospective study was performed in older patients (over 65 years) with hyponatremia, diagnosed at admission in...