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Macular OCT-angiography parameters to predict the clinical stage of nonprolifer...

Rodrigues, Tiago M.; Marques, João P.; Soares, Mário; Simão, Sílvia; Melo, Pedro; Martins, Amélia; Figueira, João; Murta, Joaquim N.; Silva, Rufino

Background: To test whether a single or a composite set of macular vascular density parameters, evaluated with optical coherence tomography angiography (OCTA), are able to predict nonproliferative diabetic retinopathy (NPDR) staging according to the gold-standard ETDRS-grading scheme. Methods: Prospectively defined, cross-sectional study in which macular structural and vascular parameters of diabetic eyes with ...


Peripapillary neurovascular coupling in the early stages of diabetic retinopathy

Rodrigues, Tiago M.; Marques, João P.; Soares, Mário; Dolan, Michael-John; Melo, Pedro; Simão, Sílvia; Teles, João; Figueira, João; Murta, Joaquim N.

Purpose: To study radial peripapillary capillary (RPC) density in the early stages of diabetic retinopathy (DR), using optical coherence tomography angiography. Methods: A cross-sectional evaluation of RPCs was performed using optical coherence tomography angiography (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Annular RPC density was the primary outcome. Global density and retinal nerve fiber layer thickne...


Functional and Structural Findings of Neurodegeneration in Early Stages of Diab...

B M Santos, Ana Rita; Ribeiro, Luísa; Bandello, Francesco; Lattanzio, Rosangela; Egan, Catherine; Frydkjaer-Olsen, Ulrik; García-Arumí, José

This cross-sectional study evaluated the relationship between 1) functional and structural measurements of neurodegeneration in the initial stages of diabetic retinopathy (DR) and 2) the presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of 449 patients with type 2 diabetes enrolled in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR) s...


Two-dimensional segmentation of the retinal vascular network from optical coher...

Rodrigues, Pedro; Guimarães, Pedro; Santos, Torcato; Simão, Sílvia; Miranda, Telmo; Serranho, Pedro; Bernardes, Rui

The automatic segmentation of the retinal vascular network from ocular fundus images has been performed by several research groups. Although different approaches have been proposed for traditional imaging modalities, only a few have addressed this problem for optical coherence tomography (OCT). Furthermore, these approaches were focused on the optic nerve head region. Compared to color fundus photography and fl...


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