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New fluorescent probes based on gallium(III) corrole complexes for the recognit...
Santos, Carla I.M.; Santiago, Ana M.; Araújo, Ana R.L.; Pinto, Sandra; Agostinho, Rafaela; Simão, Sónia; Azevedo, Tomás Pais de; Antunes, CatarinaIn this work, three fluorescent probes for detection of hydrogen sulfide (H2S) where prepared based on gallium (III) corrole complexes bearing nitro groups at beta-pyrrolic positions. Two of the compounds selected, the 3-nitro5,10,15- tris(pentafluorophenyl)corrolatogallium(III)(pyridine) (CGa-NO2) and the 3,17-dinitro-5,10,15-tris (pentafluorophenyl)corrolatogallium(III)(pyridine) (CGa-2NO2) present one and tw...
Human-derived NLS enhance the gene transfer efficiency of chitosan
Bitoque, Diogo; Morais, Joana; Oliveira, Ana; Sequeira, Raquel L.; Calado, Sofia; Fortunato, Tiago M.; Simão, Sónia; Rosa Da Costa, AnaNuclear import is considered as one of the major limitations for non-viral gene delivery systems and the incorporation of nuclear localization signals (NLS) that mediate nuclear intake can be used as a strategy to enhance internalization of exogenous DNA. In this work, human-derived endogenous NLS peptides based on insulin growth factor binding proteins (IGFBP), namely IGFBP-3 and IGFBP-5, were tested for their...
Identification of new targets of S-nitrosylation in neural stem cells by thiol ...
Santos, Ana Isabel; Lourenço, Ana Sofia; Simão, Sónia; Marques da Silva, Dorinda; Santos, Daniela Filipa; Onofre de Carvalho, Ana PaulaNitric oxide (NO) is well established as a regulator of neurogenesis. NO increases the proliferation of neural stem cells (NSC), and is essential for hippocampal injury-induced neurogenesis following an excitotoxic lesion. One of the mechanisms underlying non-classical NO cell signaling is protein S-nitrosylation. This post-translational modification consists in the formation of a nitrosothiol group (R-SNO) in ...
Identification of new targets of S-nitrosylation in neural stem cells by thiol ...
Santos, Ana Isabel; Lourenco, Ana S.; Simão, Sónia; Marques-da-Silva, Dorinda; Santos, Daniela F.; Carvalho, Ana Paula Onofre de; Pereira, Ana CatarinaNitric oxide (NO) is well established as a regulator of neurogenesis. NO increases the proliferation of neural stem cells (NSC), and is essential for hippocampal injury-induced neurogenesis following an excitotoxic lesion. One of the mechanisms underlying non-classical NO cell signaling is protein S-nitrosylation. This post-translational modification consists in the formation of a nitrosothiol group (R-SNO) in ...
Susceptibilidade do subfragmento-1 de miosina de músculo esquelético de coelho ...
Simão, SóniaFoi já demonstrado que, em disfunções cardíacas, o compartimento miofibrilar é um local de formação de peroxinitrito (ONOO-) e consequente nitrosilação das proteínas miofibrilares. Existe muito pouca informação, in vitro, acerca dos mecanismos pelos quais as proteínas miofibrilares são afectadas por esta espécie. Por este motivo, neste trabalho determinou-se a susceptibilidade do subfragmento-1 (S1) de miosina ...