4 documents found, page 1 of 1
Combined inhibition of FOSL-1 and YAP Using siRNA-lipoplexes reduces the growth...
Diego-González, Lara; Fernández-Carrera, Andrea; Igea, Ana; Martínez-Pérez, Amparo; Real Oliveira, M. Elisabete C. D.; Gomes, Andreia C; Guerra, CarmenPancreatic cancer evades most of the current therapies and there is an urgent need for new treatments that could efficiently eliminate this aggressive tumor, such as the blocking of routes driving cell proliferation. In this work, we propose the use of small interfering RNA (siRNA) to inhibit the combined expression of FOSL-1 and YAP, two signaling proteins related with tumor cell proliferation and survival. To...
Safety and efficacy assessment of aerogels for biomedical applications
Ferreira-Gonçalves, Tânia; Constantin, Carolina; Neagu, Monica; Reis, Catarina Pinto; Sabri, Firouzeh; Simón-Vázquez, RosanaThe unique physicochemical properties of aerogels have made them an attractive class of materials for biomedical applications such as drug delivery, regenerative medicine, and wound healing. Their low density, high porosity, and ability to regulate the pore structure makes aerogels ideal nano/micro-structures for loading of drugs and active biomolecules. As a result of this, the number of in vitro and in vivo s...
PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenoc...
Souza, Ludmilla Regina de; Muehlmann, Luis Alexandre; Santos, Mayara Simonelly Costa dos; Ganassin, Rayane; Simón-Vázquez, RosanaBackground: Selol is an oily mixture of selenitetriacylglycerides that was obtained as a semi-synthetic compound containing selenite. Selol is effective against cancerous cells and less toxic to normal cells compared with inorganic forms of selenite. However, Selol’s hydrophobicity hinders its administration in vivo. Therefore, the present study aimed to produce a formulation of Selol nanocapsules (SPN) and to ...
Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells
Oliveira, Ana Cristina Norberto Gonçalves; Raemdonck, Koen; Martens, Thomas; Rombouts, Koen; Simón-Vázquez, Rosana; Botelho, C. M.While the delivery of small interfering RNAs (siRNAs) is an attractive strategy to treat several clinical con- ditions, siRNA-nanocarriers stability after intravenous administration is still a major obstacle for the development of RNA-interference based therapies. But, although the need for stability is well recognized, the notion that strong stabilization can decrease nanocarriers efficiency is sometimes negle...