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Production of an extract rich in alpha-tomatine from green tomatoes by subcriti...
Faria-Silva, Catarina; Pedras, Bruno; Costa, Nuno; Carvalheiro, Manuela; Simões, Sandra; Simões, PedroResearch Institute for Medicines\u2014iMed.ULisboa is funded by FCT through project UID 04138. Publisher Copyright: © 2025 The Authors.; Green tomatoes, a by-product of agro-food industry, are rich in the glycoalkaloid alpha-tomatine. This compound presents health benefits including anti-inflammatory and fungicide properties. Subcritical water extraction (SWE), a green and sustainable process, was used to obtai...
Topical foams containing natural saponins
Faria-Silva, Catarina; Scavone, Denise; Marto, Joana; Carvalheiro, Manuela; Simões, SandraFunding Information: This research was funded by Fundação para a Ciência e a Tecnologia (FCT) through projects 2023.12853.PEX, UID//04138 and PhD fellowship 2022.11984.BD. Publisher Copyright: © 2025 The Authors; The cosmetic and pharmaceutical markets are witnessing a rising number of topical foam products, particularly for cosmetic applications, alongside a significant increase in foam-related patents in rece...
In Vitro, Ex Vivo, and In Vivo Evaluation of Silver Nanoparticles Synthesized U...
Cunha, Daniela; Faria-Silva, Catarina; Carvalho, Filomena A.; Ascensão, Lia; Simões, Pedro; Carvalheiro, Manuela; Simões, SandraPublisher Copyright: © 2024 by the authors.; Biogenic silver nanoparticles (AgNP) are among the fastest-growing nanomaterials due to the simplicity, efficiency, and sustainability of their biosynthesis using phytochemicals as reducing and coating agents. The agro-food industry generates large quantities of organic waste, a renewable source of biomolecules for AgNP biosynthesis. The main objective of this work w...
Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 C...
da Silva, Gustavo; Luz, André F.S.; Duarte, Denise; Fontinha, Diana; Silva, Vera L.M.; Almeida Paz, Filipe A.; Madureira, Ana M.; Simões, SandraFunding Information: . The authors acknowledge the financial support provided by Fundação para a Ciência e a Tecnologia (FCT Portugal) through the PhD grant research project SFRH/BD/103412/2014 and projects PTDC/MED‐QUI/30021/2017, PTDC/MED‐CAR/31322/2017 and PTDC/SAU‐TOX/32515/2017, and the research unit GHTM (UID/Multi/04413/2013 and GHTM‐UID/04413/2020). We thank MR4 for providing us with malaria parasites c...
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment
Ferreira‐silva, Margarida; Faria‐silva, Catarina; Carvalheiro, Manuela C.; Simões, Sandra; Marinho, H. Susana; Marcelino, Paulo; Campos, Maria CelestePD/BD/135264/2017 UID/DTP/04138/2020 UIDP/04138/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020 UIDB/50006/2020 UIDB/00100/2020; Ischemia and reperfusion injury (IRI) is a common complication caused by inflammation and oxidative stress resulting from liver surgery. Current therapeutic strategies do not present the desirable efficacy, and severe side effects can occur. To overcome these drawbacks, new therap...
Evaluating the presence of lycopene-enriched extracts from tomato on topical em...
Costa, Ana M.; Marques, Marta; Congiu, Franca; Paiva, Alexandre; Simões, Pedro; Ferreira, António; Bronze, Maria Rosário; Marto, JoanaUIDB/QUI/50006/2020 UIDB/04138/2020 UIDP/04138/2020 PTDC/SAU-SER/30197/2017LISBOA-01-0145-FEDER-030197 IF/01146/2015; One of the new trends of personal care industry is the use of organic ingredients derived from nature, in particular, from food-processing residues with proven efficacy. Lycopene is a carotenoid responsible for the red color of several fruits, namely tomato, whose antioxidant and photoprotective...
The secretome derived from 3D-cultured umbilical cord tissue MSCS counteracts m...
Miranda, Joana P.; Camões, Sérgio P.; Gaspar, Maria M.; Rodrigues, Joana S.; Carvalheiro, Manuela; Bárcia, Rita N.; Cruz, Pedro Estilita; Cruz, HelderRheumatoid arthritis (RA) is an autoimmune disorder whose treatment is mostly restricted to pain and symptom management and to the delay of joint destruction. Mesenchymal stem/stromal cells from the umbilical cord tissue (UC-MSCs) have previously been proven to be immunomodulatory and more efficient than bone marrow-derived MSCs in causing remission of local and systemic arthritic manifestations in vivo. Given ...