4 documents found, page 1 of 1
CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukem...
Rodrigues, Cristiana; Laranjeira, Paula; Pinho, A. C. O.; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana Catarina; Simões, Ana TeresaIntroduction: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer. Methods: Here, we quantified and phenotypically characterized CD20...
Negative MR4·0 chronic myeloid leukaemia and its possible implications for trea...
Cerveira, Nuno; Diamond, Joana; Matos, Sónia; Amorim, Maria L; Coucelo, Margarida; Bizarro, Susana; Simões, Ana Teresa; Pierdomenico, FrancescaABL1 tyrosine kinase inhibitors (TKI) have dramatically improved the outcome for chronic myeloid leukaemia (CML) patients, resulting in a life expectancy that approaches that of the general population. Nevertheless, lifelong TKI therapy may have consequences, including chronic adverse events that can substantially impact patients’ quality of life, adherence to therapy and treatment success. Recently, several cl...
Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and mot...
Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos Bandeira; Almeida, Luís Pereira deMachado–Joseph Disease (MJD) is the most prevalent autosomal dominantly inherited cerebellar ataxia. It is caused by an expanded CAG repeat in the ATXN3 gene, which translates into a polyglutamine tract within the ataxin-3 protein. Present treatments are symptomatic and do not prevent disease progression. As calpain overactivation has been shown to contribute to mutant ataxin-3 proteolysis, translocation to the...
Calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease
Simões, Ana TeresaTese de doutoramento em Farmácia, na especialidade de Biotecnologia Farmacêutica, apresentada à Faculdade de Farmácia da Universidade de Coimbra; Machado-Joseph disease, also known as spinocerebellar ataxia type 3 (MJD/SCA3), is the most frequent autosomal dominantly-inherited ataxia worldwide. MJD is caused by a CAG expansion within the coding region of MJD1 gene mapped to chromosome 14q32.1, resulting the mut...