13 documents found, page 1 of 2
MLL2/KMT2D and MLL3/KMT2C expression correlates with disease progression and re...
Rabello, Doralina do Amaral; Ferreira, Vivian D’Afonseca da Silva; Coelho, Maria Gabriela Berzoti; Burin, Sandra Mara; Magro, Cíntia LeticiaBackground Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis is linked to the Philadelphia chromosome presence that generates the BCR–ABL1 fusion oncogene. Tyrosine kinase inhibitors (TKI) such as imatinib mesylate (IM) dramatically improved the treatment efficiency and survival of CML patients by targeting BCR–ABL tyrosine kinase. The disease shows three distinct clinica...
Hematopoietic stem cell transplantation reverses white matter injury measured b...
Simões, Belinda Pinto
Consenso Brasileiro de Nutrição em Transplante de Células-Tronco Hematopoiética...
Barban, Juliana Bernardo; Simões, Belinda Pinto; Moraes, Bruna Del Guerra de Carvalho; Anunciação, Cássia Rehem da; Rocha, Cristiane Santos daThe nutritional status of patients submitted to hematopoietic stem cell transplant is considered an independent risk factor, which may influence on quality of life and tolerance to the proposed treatment. The impairment of nutritional status during hematopoietic stem cell transplant occurs mainly due to the adverse effects resulting from conditioning to which the patient is subjected. Therefore, adequate nutrit...
GVHD-derived plasma as a priming strategy of mesenchymal stem cells
Carvalho, Amandda Évelin Silva; Rodrigues, Leane Perim; Schiavinato, Josiane Lilian; Alborghetti, Marcos Rodrigo; Bettarello, GustavoBackground: Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of MSCs constitute an active area of investigation. Here, we proposed an innovative priming strategy based on the plasma obtained from GVHD patients and tested whether this approach could enhance ...
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytok...
Cacemiro, Maira da Costa; Cominal, Juçara Gastaldi; Tognon, Raquel; Nunes, Natalia de Souza; Simões, Belinda Pinto; Figueiredo-Pontes, Lorena Lôbo de-; Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods: This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed corre...
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytok...
Cacemiro, Maira da Costa; Cominal, Juçara Gastaldi; Ribeiro, Raquel Tognon; Nunes, Natalia de Souza; Simões, Belinda Pinto-; Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods: This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed corre...
Long-term outcomes after autologous hematopoietic stem cell transplantation for...
Simões, Belinda Pinto
Zika and chikungunya virus infections in hematopoietic stem cell transplant rec...
Simões, Belinda Pinto
Successful outcome of allogeneic sten cell transplantation in Seckel syndrome
Simões, Belinda Pinto
Risks, benefits, and therapeutic potential of hematopoietic stem cell transplan...
Simões, Belinda Pinto