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Tofacitinib: an Option for Acute Severe Ulcerative Colitis?

Santos, S; Gamelas, V; Saraiva, R; Simões, G; Saiote, J; Ramos, J

Tofacitinib has emerged as a new option for ulcerative colitis. Its rapid absorption, metabolism, and clinical improvement make it an interesting option for rescue therapy in acute severe ulcerative colitis (ASUC), a situation with limited therapeutic options in patients with a long-term disease course and multiple drug failure. The management of ASUC in this setting becomes challenging, underlying the need for...


Syphilitic Hepatitis: a Rare Complication of Secondary Syphilis. A Case Report

Caldeira, M; João, AL; Pestana, M; Canha, I; Simões, G; Fernandes, C

Syphilis is a sexually transmitted disease caused by Treponema pallidum, progressing through active and latent stages if left untreated. Hepatic involvement can occur in secondary syphilis, but this is an uncommon complication, with few published case reports. A 34-year-old man without significant medical history was admitted to the gastroenterology department with a 2-week history of unexplained jaundice and a...


Primary Liver Lymphoma Presenting as Liver Nodules

Silva, JM; Ornelas Saraiva, R; Simões, G; Araújo, C; Calinas, F; Coimbra, J

The liver is usually affected in advanced stages of lympho-proliferative diseases, but primary liver lymphomas (PLLs) are rare. The diagnosis is usually late, especially in patients without identifiable risk factors, with consequent worse prognosis. We report the case of a 59-year-old female with progressive worsening pain in the right hypochondrium and weight loss. She was previously healthy and had a family h...


Response Regarding: Endoscopic Management of Sigmoid Volvulus in a Debilitated ...

Simões, G; Coelho da Rocha, M; Capela, T; Silva, MJ; Ramos, G; Coimbra, J


Cytomegalovirus Colitis Mimicking Rectal Tumour in an Undiagnosed HIV Patient

Rocha, M; Borges, V; Simões, G; Santos, S; Gamelas, V; Bernardes, C

Introduction: Cytomegalovirus (CMV) is the most common opportunistic agent in HIV-infected patients. It can affect the entire gastrointestinal tract, but frequently involves the oesophagus and the colon. Case Report: We report the case of a 70-year-old female, ultimately diagnosed with HIV infection, whose inaugural clinical manifestation was CMV colitis with endoscopic findings resembling a rectal tumour in wh...


Seguindo o Alfabeto...Para Diagnóstico de Hepatite Aguda E: Caso Clínico

Janeiro, C; Simões, G; Santos, R; Teixeira, J; Vale, L

Classicamente a hepatite viral está associada ao vírus da hepatite A, B ou C, podendo ser também causada por outros vírus. Apesar de não ser endémica em Portugal, reporta-se o caso esporádico de uma doente com hepatite aguda, cujo diagnóstico se confirmou hepatite E. Os autores chamam a atenção para uma causa rara de hepatite, devendo ser um diagnóstico a considerar após exclusão de causas mais frequentes.


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