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Interactions between Rhodamine Dyes and Model Membrane Systems — Insights from ...

Magalhães, Nisa; Simões, Guilherme M.; Cristiana, Ramos; Samelo, Jaime; Oliveira, Alexandre C.; Filipe, Hugo A. L.; Prates Ramalho, João P.

Background: rhodamines are dyes widely used as fluorescent tags in cell imaging, probing of mitochondrial membrane potential, and as P-glycoprotein model substrates. In all these applications, detailed understanding of the interaction between rhodamines and biomembranes is fundamental. Methods: we combined atomistic molecular dynamics (MD) simulations and fluorescence spectroscopy to characterize the interactio...


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