5 documents found, page 1 of 1
Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adu...
Vilela, Márcia Carvalho; Barichello, Tatiana; Generoso, Jaqueline S.; Simões, Lutiana R.; Elias, Samuel G.; Tashiro, Michael H.; Dominguini, DiogoStreptococcus pneumoniae is a common cause of forms of bacterial meningitis that have a high mortality rate and cause long-term neurologic sequelae. We evaluated the effects of an indoleamine 2,3-dioxygenase (IDO) inhibitor on proinflammatory mediators and memory in Wistar rats subjected to pneumococcal meningitis. The animals were divided into 4 groups: sham, sham treated with IDO inhibitor, meningitis, and me...
Cannabidiol reduces host immune response and prevents cognitive impairments in ...
Barichello, Tatiana; Ceretta, Renan A.; Generoso, Jaqueline S.; Moreira, Ana Paula; Simões, Lutiana R.; Comim, Clarissa M.; Quevedo, JoãoPneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment of learning and memory. The aim of this study was to evaluate the effects of acute and extended admi...
Neonatal Escherichia coli K1 meningitis causes learning and memory impairments ...
Vilela, Márcia Carvalho; Barichello, Tatiana; Dagostim, Valdemira S.; Generoso, Jaqueline S.; Simões, Lutiana R.; Dominguini, Diogo; Silvestre, CintiaNeonatal Escherichia coli meningitis continues to be an important cause of mortality and morbidity in newborns worldwide. The aim of this study was to investigate the cytokines/chemokines, brain-derived neurotrophic factor (BDNF) levels, blood–brain barrier integrity in neonatal rats following E. coli K1 experimental meningitis infection and subsequent behavioural parameters in adulthood. In the hippocampus, in...
Brain–blood barrier breakdown and pro-inflammatory mediators in neonate rats su...
Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Moreira, Ana Paula; Costa, Caroline S.; Zanatta, Jessiele R.; Simões, Lutiana R.Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured bra...
Environmental enrichment restores cognitive deficits induced by experimental ch...
Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Dagostin, Caroline S.; Simões, Lutiana R.; Vilela, Márcia C.; Comim, Clarissa M.To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 × 106 CFU/mL and remained with their mothers unt...