Encontrados 26 documentos, a visualizar página 1 de 3

Visible-light photoactivated proanthocyanidin and kappa-carrageenan coating wit...

The increase of bacterial resistance to antibiotics is a growing concern worldwide and the search for new therapies could cost billions of dollars and countless lives. Inert surfaces are major sources of contamination due to easier adhesion and formation of bacterial biofilms, hindering the disinfection process. Therefore, the objective of this study was to develop a photoactivatable and anti-adhesive kappa-car...

Phytochemicals and quaternary phosphonium ionic liquids: Connecting the dots to...

Introduction: The infections by multidrug-resistant bacteria are a growing threat to human health, and the efficacy of the available antibiotics is gradually decreasing. As such, new antibiotic classes are urgently needed. Objectives: This study aims to evaluate the antimicrobial activity, safety and mechanism of action of phytochemical-based triphenylphosphonium (TPP') conjugates. Methods: A library of phytoch...

Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics ag...

The treatment of bacterial infections has been troubled by the increased resistance to antibiotics, instigating the search for new antimicrobial therapies. Phytochemicals have demonstrated broad-spectrum and effective antibacterial effects as well as antibiotic resistance-modifying activity. In this study, perillyl alcohol and hydrocinnamic acid were characterized for their antimicrobial action against Escheric...

The action of phytochemicals in biofilm control

Covering: 2009 to 2021 Antimicrobial resistance is now rising to dangerously high levels in all parts of the world, threatening the treatment of an ever-increasing range of infectious diseases. This has becoming a serious public health problem, especially due to the emergence of multidrug-resistance among clinically important bacterial species and their ability to form biofilms. In addition, current anti-infect...

Inovar a praxe: integração numa escola de enfermagem promotora de saúde – Escol...

A 7 Year Old Girl with Vaginal Burn from Exposure to an Alkaline Battery

Background: Vaginal burns resulting from alkaline batteries are a rare and potential serious complication which require a prompt intervention. Case: A 7-year-old girl presented to the emergency department with lower abdominal pain, dysuria and brownish vaginal discharge. Clinical history suggested a foreign body. Abdominal radiography showed two alkaline batteries inside the vagina that were removed. Vaginoscop...

Discovery of a small-molecule protein kinase Cd-selective activator with promis...

Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, we report the first small-molecule PKCd-selective activator, the 7a-acetoxy-6ß-benzoyloxy-12-O-benzoylroyleanone (R...

Humanitude: Realização da Humanidade numa Sociedade Tecnológica

Identification of a novel deletion in SURF1 gene: Heterogeneity in Leigh syndro...

Leigh syndrome (LS) is a rare, progressive neurodegenerative mitochondrial disorder of infancy. It is a genetically heterogeneous disease. The mutations in SURF1 gene are the most frequently known cause. Here two cases of LS likely caused by SURF1 gene variants are reported: a 39-year-old male patient with a novel homozygous deletion (c.-11_13del), and a case of a 6-year-old boy with the same deletion and a non...

Integration of microalgae-based bioenergy production into a petrochemical compl...

The rapid development of modern society has resulted in an increased demand for energy, mainly from fossil fuels. The use of this source of energy has led to the accumulation of carbon dioxide (CO2) in the atmosphere. In this context, microalgae culturing may be an effective solution to reduce the CO2 concentration in the atmosphere, since these microorganisms can capture CO2 and, simultaneously, produce bioene...