122 documents found, page 1 of 13
Beyond penicillin: the potential of filamentous fungi for drug discovery in the...
Correia, João; Borges, Anabela; Simões, M.; Simões, Lúcia ChavesAntibiotics are a staple in current medicine for the therapy of infectious diseases. However, their extensive use and misuse, combined with the high adaptability of bacteria, has dangerously increased the incidence of multi-drug-resistant (MDR) bacteria. This makes the treatment of infections challenging, especially when MDR bacteria form biofilms. The most recent antibiotics entering the market have very simil...
Bioprospection of antibiotics and biofilm inhibitors from under-exploited filam...
Correia, J.; Borges, A.; Simões, M.; Soares, Célia; Lima, Nelson; Simões, Lúcia ChavesIn the past century, millions of lives were saved by antibiotics, which treat some of the historically more deadly diseases. However, bacteria may quickly develop antibiotic resistance and the speed of development of new drugs has decreased significantly in the last decades. Filamentous fungi have a great potential for novel antibiotic discovery, given their vast, largely unexplored metabolome. The One Strain M...
Methylparaben as a concerning environmental pollutant compromising drinking wat...
Pereira, A. R.; Gomes, I.; Simões, M.Background: Drinking water distribution systems are known to harbor biofilms, even after disinfection, which constitute a source of microorganisms that may remain in the drinking water (DW) delivered through a consumer's tap [1]. Nevertheless, the presence of parabens (an anthropogenic contaminant) in DW is another problem that may affect microbial characteristics and the susceptibility to chlorine, compromisin...
The impact of potassium peroxymonosulphate and chlorinated cyanurates on biofil...
Oliveira, I. M.; Gomes, I. B.; Plácidoc, A.; Simões, Lúcia Chaves; Eaton, P.; Simões, M.The activity of two chlorinated isocyanurates (NaDCC and TCCA) and peroxymonosulphate (OXONE) was evaluated against biofilms of Stenotrophomonas maltophilia, an emerging pathogen isolated from drinking water (DW), and for the prevention of biofilm regrowth. After disinfection of pre-formed 48 h-old biofilms, the culturability was reduced up to 7 log, with OXONE, TCCA, and NaDCC showing more efficiency than free...
O contributo do GO FruitFlyProtect para melhorar a proteção contra a drosófila-...
Figueiredo, E.; Godinho, Maria; Simões, M.; Alexandre, P.; Mendonça, T.; Oliveira, M.; Mateus, C.; Valério, Elsa; Mexia, A.Apresentam-se os resultados obtidos no GO FruitFlyProtect relativos às capturas de Drosophila suzukii em armadilhas (dispositivo e isco), para estimativa do risco ou para captura em massa. Utilizaram-se os dispositivos das marcas Econex, Koppert, Biobest, com o isco respetivo, e garrafa PET e dispositivo “Lasa”, construídos artesanalmente e iscados com composto de vinagre da empresa Mendes & Gonçalves Lda. Na a...
Cyclic voltammetry study of a yeast-based microbial fuel cell
Vilas Boas, J.; Peixoto, L.; Oliveira, V. B.; Simões, M.; Pinto, A. M. F. R.Microbial fuel cells (MFCs) using yeasts are known to produce less energy than those using bacteria. However, yeasts offer a plethora of advantages that can be used to MFCs profit. In this work, the electrochemical behavior of Zygosaccharomyces bailii was investigated by cyclic voltammetry, using a synthetic winery wastewater. The voltammograms revealed different oxidation-reduction peaks that could be associat...
Biofilm formation under high shear stress increases resilience to chemical and ...
Simões, Lúcia Chaves; Gomes, I. B.; Sousa, H.; Borges, A.; Simões, M.The effect that the hydrodynamic conditions under which biofilms are formed has on their persistence is still unknown. This study assessed the behaviour of Pseudomonas fluorescens biofilms, formed on stainless steel under different shear stress (sw) conditions (1, 2 and 4 Pa), to chemical (benzalkonium chloride – BAC, glutaraldehyde – GLUT and sodium hypochlorite – SHC) and mechanical (20 Pa) treatments (alone ...
Influence of surface copper content on Stenotrophomonas maltophilia biofilm con...
Gomes, I. B.; Simões, Lúcia Chaves; Simões, M.This work aimed to evaluate the action of materials with different copper content (0, 57, 96 and 100%) on biofilm formation and control by chlorination and mechanical stress. Stenotrophomonas maltophilia isolated from drinking water was used as a model microorganism and biofilms were developed in a rotating cylinder reactor using realism-based shear stress conditions. Biofilms were characterized phenotypically ...
Utilização de radiação Ultravioleta (UV-C) como tecnologia alternativa aos sulf...
Alves, M.; Grácio, J.; Simões, M.; Mira, H.Neste trabalho avaliou-se o efeito da radiação UV-C sobre a estabilidade microbiológica do vinho tinto e, também, a sua influência sobre alguns parâmetros físico-químicos e sobre o perfil sensorial. Assim, o vinho sem sulfitos foi submetido a radiação UV-C com duas doses diferentes, 778 J.L‑1 e 1415 J.L‑1, e procedeu-se ainda à preparação de um controlo a que foi adicionado 40 mg.L‑1 de dióxido de enxofre. Os v...
The effects of pharmaceutical and personal care products on the behavior of Bur...
Gomes, I. B.; Madureira, D.; Simões, Lúcia C.; Simões, M.The presence of pharmaceutical and personal care products (PPCPs) in water environments has been extensively reported, particularly at trace concentrations in drinking water (DW). Nevertheless, there is a lack of information on the possible effects of the presence of PPCPs on the microbiota of drinking water distribution systems (DWDS). This pioneer study aims to understand the effects of exposure to selected P...