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The effects of methylparaben exposure on drinking water bacteria virulence and ...
Pereira, Ana; Grenho, Liliana; Gomes, Inês; Simões, ManuelBackground: Parabens, widely used as preservatives in personal care products, pose an increased global concern due to their impact on environmental microbial communities, particularly in drinking water (DW), and potential risks to public health. Among different parabens detected in drinking water distribution systems (DWDS), methylparaben (MP) is the most prevalent at elevated concentrations, raising serious he...
Development of new phytochemical-based disinfectant formulations for the contro...
Sousa, Mariana; Borges, Anabela; Simões, ManuelBackground: Healthcare-associated infections (HAIs) remain a critical public health challenge due to the persistence of multidrug-resistant (MDR) bacteria and the inefficacy of conventional disinfectants [1]. Biofilms further enhance bacterial resistance and limit the effectiveness of biocides [2]. Phytochemicals have emerged as natural alternatives due to their antimicrobial and antibiofilm properties [3]. Thi...
Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa biofilms: a s...
Gonçalves, Ariana S. C.; Simões, Manuel; Borges, AnabelaBackground: Chronic wound infections caused by Pseudomonas aeruginosa biofilms are highly resistant to conventional treatments, necessitating innovative therapeutic strategies [1]. Antimicrobial photodynamic inactivation (aPDI) has proven to be a promising alternative [2]. However, its efficacy against Gram-negative bacteria remains suboptimal due to the restricted penetration of light and photosensitizers thro...
Targeting quorum sensing: ferulic and sinapic acids compromise Pseudomonas aeru...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that is frequently associated with chronic infections in immunocompromised individuals, such as those with cystic fibrosis or burns [1]. The pathogenicity and virulence of P. aeruginosa are primarily regulated by quorum sensing, with the las system playing a key role in this process. This system is essential for the formation and mainten...
Photodynamic inactivation of methicillin-resistant Staphylococcus aureus using ...
Teixeira, Lília; Fraga, Sónia; Simões, Manuel; Borges, AnabelaBackground: Antibiotic-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), pose significant challenges in the treatment of chronic wound infections. Antibacterial photodynamic therapy (aPDT) offers a localized, resistance-independent alternative to antibiotics [1]. In aPDT, bacteria are targeted by molecules called photosensitizers (PSs) that are activated by light. Natural PSs are ...
The potential of selected natural products as biofilm control agents and antibi...
Massano, Francisca; Sousa, Mariana; Borges, Anabela; Simões, ManuelBackground: The emergence of multidrug-resistant bacteria, especially within biofilms, poses a serious public health threat and represents a major challenge for effective infection management. Traditional antibiotics often fail to effectively treat bacteria and biofilm-associated infections, prompting the need for novel strategies to combat bacterial resistance and biofilm formation. Natural compounds, such as ...
Biocides as drivers of antibiotic resistance: A critical review of environmenta...
Sousa, Mariana; Machado, Idalina; Simões, Lúcia Chaves; Simões, ManuelThe widespread and indiscriminate use of biocides poses significant threats to global health, socioeconomic development, and environmental sustainability by accelerating antibiotic resistance. Bacterial resistance development is highly complex and influenced significantly by environmental factors. Increased biocide usage in households, agriculture, livestock farming, industrial settings, and hospitals produces ...
Current microbiological challenges in drinking water
Afonso, Ana C.; Saavedra, Maria J.; Gomes, Inês B.; Simões, Manuel; Simões, Lúcia ChavesDrinking water (DW) is paramount to human health, serving as a cornerstone of public health worldwide. However, DW is not a sterile product and can harbor a large diversity of microorganisms, including pathogens. This comprehensive review addresses the critical importance of DW for human health and the ongoing challenges posed by microbial pathogens and biofilms in water distribution systems. It further analyze...
The role of the proteosurfaceome and exoproteome in bacterial coaggregation
Afonso, Ana C.; Saavedra, Maria J.; Simões, Manuel; Simões, Lúcia ChavesBacterial coaggregation is a critical process in multispecies biofilm formation, driven by specific molecular interactions that facilitate the adhesion and aggregation of bacterial cells. These interactions are essential for the development and persistence of complex microbial communities. This review provides a comprehensive analysis of the roles of the proteosurfaceome and exoproteome in bacterial coaggregati...
Influence of bacterial load on the development and performance of a photohetero...
Sousa, Henrique; Simões, Lúcia Chaves; Sousa, Cátia A.; Simões, ManuelA novel photoheterotrophic dual-species biofilm was evaluated for wastewater (WW) treatment and microbial growth under variable cell loads. For that, Chlorella vulgaris was tested under axenic conditions and in combination with three bacteria, Rhodococcus fascians, Acinetobacter calcoaceticus, and Leucobacter sp., assessing the influence of each bacterial strain in biomass productivity, growth rate, thickness, ...