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Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke

Stroke represents the second leading cause of mortality and morbidity worldwide. Ischemic strokes are the most prevalent type of stroke, and they are characterized by a series of pathological events prompted by an arterial occlusion that leads to a heterogeneous pathophysiological response through different hemodynamic phases, namely the hyperacute, acute, subacute, and chronic phases. Stroke treatment is highl...

Real-world data from the Portuguese Nivolumab Expanded Access Program (EAP) in ...

OBJECTIVE: The main aim of the study was to evaluate the efficacy and safety profile of Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, in a real world setting. METHODS: We performed a retrospective, multicentre data analysis of patients who were included in the Portuguese Nivolumab Expanded Access Program (EAP). Eligibility crite...

Animal Models of Acute Gastric Mucosal Injury: Macroscopic and Microscopic Eval...

Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely used rat models of acute gastric ulcer, the ethanol-induced ulcer and the indomethacin-induced ulcer. These two models are compared in terms of macroscopic and microscopic features. Experimentally,...

Multidisciplinary Portuguese recommendations on DXA request and indication to t...

OBJECTIVE: To establish Portuguese recommendations regarding the indication to perform DXA and to initiate medication aimed at the prevention of fragility fractures. METHODS: A multidisciplinary panel, representing the full spectrum of medical specialties and patient associations devoted to osteoporosis, as well as national experts in this field and in health economics, was gathered to developed recommendations...

Radiologia do Grande Traumatizado

The Portuguese who could no longer speak French: primary progressive aphasia in...

Hypochondriacal symptoms as the first sign of frontotemporal dementia

Ekbom's syndrome as the first manifestation of diabetes mellitus

Ciproterone Effect on Compulsive Masturbation in a Frontotemporal Dementia Patient

Psychotic-like experiences, emotional and behavioral problems in nonclinical ad...