Encontrados 25 documentos, a visualizar página 1 de 3
Proton Pump Inhibitors Prescription Patterns: A Retrospective Analysis of Inter...
Carlos; Santos, Sandra; Simões, Sandra; Fortuna, Jorge; Ribeiro, PedroIntroduction: Proton pump inhibitors (PPIs) have revolutionized the treatment of various medical conditions, including gastroesophageal reflux disease and peptic ulcer disease. Due to their affordability, widespread availability, and favourable safety profile, they are among the most commonly prescribed medications today. However, they are often prescribed without a valid medical reason, a practice that can be ...
Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 C...
da Silva, Gustavo; Luz, André F. S.; Duarte, Denise; Fontinha, Diana; Silva, Vera L. M.; Almeida Paz, Filipe A.; Madureira, Ana M.; Simões, SandraA multistep and diversity-oriented synthetic route aiming at the A3 coupling/domino cyclization of o-ethynyl anilines, aldehydes and s-amines is described. The preparation of the corresponding precursors included a series of transformations, such as haloperoxidation and Sonogashira cross-coupling reactions, amine protection, desilylation and amine reduction. Some products of the multicomponent reaction underwen...
Facile access to structurally diverse antimalarial indoles using a one‐pot A3 c...
Silva, Gustavo Da; Luz, André F. S.; Duarte, Denise; Fontinha, Diana; Silva, Vera L. M.; Almeida Paz, Filipe A.; Madureira, Ana MargaridaA multistep and diversity-oriented synthetic route aiming at the A3 coupling/domino cyclization of o-ethynyl anilines, aldehydes and s-amines is described. The preparation of the corresponding precursors included a series of transformations, such as haloperoxidation and Sonogashira cross-coupling reactions, amine protection, desilylation and amine reduction. Some products of the multicomponent reaction underwen...
Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regenerati...
Francisco, Pedro; Neves Amaral, Mariana; Neves, Afonso; Ferreira-Gonçalves, Tânia; Viana, Ana S.; Catarino, José; Faísca, Pedro; Simões, SandraPresently, skin burns are considered one of the main public health problems and lack therapeutic options. In recent years, silver nanoparticles (AgNPs) have been widely studied, playing an increasingly important role in wound healing due to their antibacterial activity. This work is focused on the production and characterization of AgNPs loaded in a Pluronic® F127 hydrogel, as well as assessing its antimicrobia...
Innovative, Sugar-Free Oral Hydrogel as a Co-administrative Vehicle for Pediatr...
Pereira, Margarida; Cosme Silva, Filipa; Simões, Sandra; Ribeiro, Helena; Almeida, António José; Marto, JoanaPalatability and swallowability in the pediatric population are perceived as true challenges in the oral administration of medication. Pediatric patients have high sensitivity to taste and reduced ability to take solid dosage forms, which can often lead to a poor therapeutic compliance. It is crucial to find new strategies to simplify the oral administration of drugs to children. The present paper reports the d...
Innovative, Sugar-Free Oral Hydrogel as a Co-administrative Vehicle for Pediatr...
Pereira, Margarida; Cosme Silva, Filipa; Simões, Sandra; Ribeiro, Helena Margarida; Almeida, António José; Marto, JoanaPalatability and swallowability in the pediatric population are perceived as true challenges in the oral administration of medication. Pediatric patients have high sensitivity to taste and reduced ability to take solid dosage forms, which can often lead to a poor therapeutic compliance. It is crucial to find new strategies to simplify the oral administration of drugs to children. The present paper reports the d...
3D-MSCs A151 ODN-Loaded Exosomes Are Immunomodulatory And Reveal A Proteomic Ca...
P Camões, Sérgio; Bulut, Ozlem; Yazar, Volkan; Gaspar, Maria Manuela; Simões, Sandra; Ferreira, Rita; Vitorino, Rui; Santos, Jorge M.; Gursel, IhsanIntroduction Non-healing wounds remain a major burden due to the lack of effective treatments. Mesenchymal stem cell-derived exosomes (MSC-Exo) have emerged as therapeutic options given their pro-regenerative and immunomodulatory features. Still, little is known on the exact mechanisms mediated by MSC-Exo. Importantly, modulation of their efficacy through 3D-physiologic cultures together with loading strategies...
Sustainable valorization of food-processing industry by-products: challenges an...
Simões, Sandra; Costa, Ana; Faria-Silva, Ana Catarina; Ascenso, Andreia; Marto, Joana; Carvalheiro, Manuela; Gonçalves, Lídia; Marques, M.; Paiva, A.The food-processing industry generates large quantities of residues, which may represent sustainable and rich sources of bioactive compounds. The extraction of bioactives from industrial residues could be a good alternative for the valorization of this by-product with recognized biological actions. Conventional extraction methods consume large volumes of organic solvents, which are expensive, toxic, and hazardo...
Novel Antiretroviral Therapeutic Strategies for HIV.
Cunha, Rita F.; Simões, Sandra; Carvalheiro, Manuela; Azevedo-Pereira, José Miguel; Santos-Costa, Quirina; Ascenso, AndreiaWhen the first cases of HIV infection appeared in the 1980s, AIDS was a deadly disease without any therapeutic alternatives. Currently, there is still no cure for most cases mainly due to the multiple tissues that act as a reservoir for this virus besides the high viral mutagenesis that leads to an antiretroviral drug resistance. Throughout the years, multiple drugs with specific mechanisms of action on distinc...
Increased therapeutic efficacy of SLN containing Etofenamate and Ibuprofen in t...
Mancini, Giuliana; Gonçalves, Lídia; Marto, Joana; Carvalho, Filomena Almeida; Simões, Sandra; Ribeiro, Helena; Almeida, António JoséInnovative formulations, including solid lipid nanoparticles (SLNs), have been sought to improve skin permeation of non-steroidal anti-inflammatory drugs (NSAIDs). The present study explores the use of SLNs, prepared using a fusion-emulsification method, to increase skin permeation and in vivo activity of two relevant NSAIDs: A liquid molecule (etofenamate) and a solid one (ibuprofen), formulated in a 2% hydrox...