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Evolução analítica no Serviço de Química e Toxicologia Forenses. Os últimos 20 ...

A capacidade de um laboratório forense para responder adequadamente às solicitações analíticas que lhe são dirigidas depende não apenas da qualificação dos seus recursos humanos, mas, também, em larga medida, da tecnologia disponível. É por isso da maior importância que os laboratórios disponham de equipamentos analíticos adequados aos desafios e solicitações atuais, o que inclui a deteção de fármacos recentes,...

Detection and quantification of selected cannabinoids in oral fluid samples by ...

Cannabis is the most widely consumed illicit drug worldwide. As consumption rates increase, partially due to the decriminalization of its use for medicinal and recreational purposes, analytical methods for monitoring different cannabinoids in several biological matrices have been developed. Herein, a simple and fast extraction procedure to extract natural cannabinoids from oral fluid (OF) samples was developed ...

Cannabis: Comparação entre os relatórios internacionais e a casuística do SQTF ...

Os últimos relatórios publicados pelo EMCDDA (European Monitoring Centre for Drugs and Drugs Addiction) Europol e UNODC (United Nations Office on Drugs and Crime) confirmam que a cannabis é droga de abuso mais popular no mundo nas suas duas principais formas: marijuana (folhas e flores secas) e haxixe (resina). Atualmente, estimase que existe produção de cannabis em 190 países. Nesse sentido, os últimos estudos...

New Psichoactive Substances – Un desafio para los laboratórios de toxicología f...

Near-Infrared Light Activated Formulation for the Spatially Controlled Release ...

The CRISPR/Cas9 system has emerged as a promising platform for gene editing; however, the lack of an efficient and safe delivery system to introduce it into cells continues to hinder clinical translation. Here, we report a rationally designed gene-editing nanoparticle (NP) formulation for brain applications: an sgRNA:Cas9 ribonucleoprotein complex is immobilized on the NP surface by oligonucleotides that are co...

Shape-versatile fixed cellular materials for multiple target immunomodulation

Therapeutic cells are usually administered as living agents, despite the risks of undesired cell migration and acquisition of unpredictable phenotypes. Additionally, most cell-based therapies rely on the administration of single cells, often associated with rapid in vivo clearance. Three-dimensional cellular materials may be useful to prolong the effect of cellular therapies and offer the possibility of creatin...

Documenting human exposure to cannabinoids using oral fluid

The importance of studying non-conventional biological matrices such as oral fluid (OF) is increasingly being recognized. This sample presents several advantages, mainly related to its collection procedure: it is non-invasive, easy to perform by non-medical personnel, can be performed under supervision to prevent adulteration, and provides low biohazard risk. OF samples are more likely to contain parent drugs, ...

Desenvolvimento e validação de um método analítico para a determinação de canab...

A canábis é a droga de abuso mais consumida na Europa, pelo que várias metodologias analíticas têm sido desenvolvidas para a quantificação dos seus componentes em matrizes biológicas, especialmente sangue e urina. No entanto, cada vez mais se está a reconhecer a importância do estudo de matrizes biológicas não-convencionais, nomeadamente cabelo e fluido oral (ou saliva) – os seus procedimentos de recolha não sã...

A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts

Messenger RNA (mRNA)-based therapies offer enhanced control over the production of therapeutic proteins for many diseases. Their clinical implementation warrants formulations capable of delivering them safely and effectively to target sites. Owing to their chemical versatility, polymeric nanoparticles can be designed by combinatorial synthesis of different ionizable, cationic, and aromatic moieties to modulate ...

Author Correction: Efficient spatially targeted gene editing using a near-infra...