7 documents found, page 1 of 1
Standardised comparison of limonene-derived monoterpenes identifies structural ...
Sousa, Cátia; Leitão, Alcino Jorge; Neves, Bruno Miguel; Judas, Fernando; Cavaleiro, Carlos; Mendes, Alexandrina F.Mint species are widely used in traditional and conventional medicine as topical analgesics for osteoarthritic pain and for disorders of the gastrointestinal and respiratory tracts which are all associated with chronic inflammation. To identify the structural determinants of anti-inflammatory activity and potency which are required for chemical optimization towards development of new anti-inflammatory drugs, a ...
Artroplastia total da anca: aspetos biomecânicos, biológicos e clínicos
Ramos, António; Judas, Fernando; Fonseca, Fernando; Simões, JoséSem resumo disponível.
Expression and function of K(ATP) channels in normal and osteoarthritic human c...
Rufino, Ana T.; Rosa, Susana C.; Judas, Fernando; Mobasheri, Ali; Lopes, M. Celeste; Mendes, Alexandrina F.ATP‐sensitive potassium [K(ATP)] channels sense intracellular ATP/ADP levels, being essential components of a glucose‐sensing apparatus in various cells that couples glucose metabolism, intracellular ATP/ADP levels andmembrane potential. These channels are present in human chondrocytes, but their subunit composition and functions are unknown. This study aimed at elucidating the subunit composition of K(ATP) cha...
Necrotizing Faciitis after Shoulder Mobilization and Intra-Articular Infiltrati...
Bento-Rodrigues, Joana; Judas, Fernando; Pedrosa Rodrigues, Jorge; Oliveira, João; Simões, Pedro; Lucas, Francisco; Pais Lopes, AntónioNecrotizing Fasciitis is a rapidly progressive, potentially fatal infection of superficial fasciae and subcutaneous tissue, usually resulting from an inciting trauma to the skin. Medical literature refers few cases of necrotizing fasciitis related to intra-articular infiltrations, that often lead to patients death. This report describes the clinical events on a 55 year-old diabetic patient who developed upper e...
Assessment of strategies to increase chondrocyte viability in cryopreserved hum...
Rosa, Susana Carvalho; Gonçalves, Juliana; Judas, Fernando; Lopes, Celeste; Mendes, Alexandrina FerreiraObjective: Allogeneic cartilage is used to repair damaged areas of articular cartilage, requiring the presence of living chondrocytes. So far, no preservation method can effectively meet that purpose. Identification of more effective cryoprotective agents (CPAs) can contribute to this goal. The aim of this study was to determine whether the glycosylated hydroquinone, arbutin, alone or in combination with low co...
Screening of Five Essential Oils for Identification of Potential Inhibitors of ...
Neves, Ângela; Rosa, Susana; Gonçalves, Juliana; Rufino, Ana; Judas, Fernando; Salgueiro, Lígia; Lopes, Celeste; Cavaleiro, CarlosNuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...
Impaired glucose transporter-1 degradation and increased glucose transport and ...
Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando; Mobasheri, Ali; Lopes, Celeste; Mendes, Alexandrina FerreiraIntroduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intr...