56 documents found, page 1 of 6
Imbalance between the cellular proliferation and death in harderian gland of fe...
Araújo,Ariadne Stavare Leal; Verna,Carina; Araújo Júnior,Osvaldo Pereira; Soares Júnior,José Maria; Simões,Ricardo Santos; Baracat,Edmund ChadaSUMMARY OBJECTIVE: To assess the impact of the metoclopramide-induced hyperprolactinemia in cellular death and proliferation in the harderian gland of female mice. METHODS: Twenty female mice were divided into two groups of 10 animals each and treated: 0.2 mL of saline solution (controls, Ctr) and 200 µg of metoclopramide (experimental, hyperprolactinemia), both for 50 consecutive days and at 12:00 a.m. On the ...
Histological analysis of the intestinal wall of newborn rats submitted to hypox...
Silvares,Soraia Guerra; Moron,Antonio Fernandes; Simões,Manuel de Jesus; Cintra,Álvaro Ulhoa; Montero,Edna Frasson de Souza; Araujo Júnior,EdwardAbstract Purpose To evaluate the effect of N-Acetylcysteine (NAC) in newborn rats submitted to hypoxia and reoxygenation (H/R) conditions in an experimental model of necrotizing enterocolitis. Methods Eight pregnant rats and their 70 cubs were used (5 groups) and exposed to H/R conditions and received NAC at different times. The animals in the H/R groups were placed in a gas chamber (100% CO2) for 10 minutes an...
The influence of phytoestrogens or estrogens on the proliferation of the rat en...
Franco,Paulo Celso; Simões,Ricardo Santos; Carbonel,Adriana Aparecida Ferraz; Sasso,Gisela Rodrigues da Silva; Florencio-Silva,RinaldoSUMMARY INTRODUCTION Although estrogen therapy is widely used against post-menopausal symptoms, it can present adverse effects, including endometrial cancer. Soy isoflavones are considered a possible alternative to estrogen therapy. However, there are still concerns whether isoflavones exert trophic effects on the uterine cervix. OBJECTIVES To evaluate the histomorphometric and immunohistochemical alterations i...
Osteoporosis and autophagy: What is the relationship?
Florencio-Silva,Rinaldo; Sasso,Gisela Rodrigues da Silva; Simões,Manuel de Jesus; Simões,Ricardo Santos; Baracat,Maria Cândida PinheiroSummary Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to sev...
Effect of folic acid in a modified experimental model of anorectal malformation...
Faria,Danilo José Fiorindo; Simões,Manuel de Jesus; Teixeira,Luciana Cristina; Faria,Angela Tucci Pinheiro; Cintra,Álvaro Edmundo Simões UlhoaPURPOSE: To determine the effect of a single dose of adriamycin (ADR) to induce anorectal malformations (ARMs) and determine the effect of folic acid (FA) in this model. METHODS: Ten female Wistar rats were divided randomly in two groups. Group A - ADR; Group B - FA+ADR. Dams from group B received daily, since two weeks before the pregnancy to the end of pregnancy, FA (50mg/kg) by gavage. Dams from both groups ...
Real time echo-guided endolaser for thermal ablation without perivenous tumescence
Gaspar,Ricardo José; Castro,André Nóbrega; Simões,Manuel de Jesus; Plapler,HélioAbstract Background There is no consensus in the medical literature on the ideal procedure for endovenous laser application. Objective To assess the safety and efficacy of real time echo-guided endovenous laser for thermal ablation of great saphenous vein (GSV) incompetence, without perivenous tumescence. Methods Thirty-four limbs of patients with CEAP clinical scores of 2 to 6 and bilateral incompetence of the...
Is it possible folic acid reduce anorectal malformations ethylenethiourea induc...
Faria,Danilo José Fiorindo; Simões,Manuel de Jesus; Martins,José LuizPURPOSE: To investigate the effect of folic acid (FA) in an experimental model of anorectal malformations (ARMs) ethylenethiourea (ETU) induced.METHODS:Eight female Wistar rats were divided randomly in two groups. Group A - ETU; Group B - FA+ETU; Dams from group B received daily, since two weeks before pregnancy to the end of pregnancy, FA (50mg/kg) by gavage. Dams from groups A and B, received 1% ETU (125mk/kg...
Effects of melatonin and prolactin in reproduction: review of literature
Tenorio,Fernanda das Chagas Angelo Mendes; Simões,Manuel de Jesus; Teixeira,Valéria Wanderley; Teixeira,Álvaro Aguiar CoelhoSummary The pineal gland is responsible for producing a hormone called melatonin (MEL), and is accepted as the gland that regulates reproduction in mammals. Prolactin (PRL) also exhibits reproductive activity in animals in response to photoperiod. It is known that the concentrations of PRL are high in the summer and reduced during winter, the opposite of what is seen with melatonin in these seasons. In placenta...
The role of N-acetyl-cysteine in the lung remote injury after hepatic ischemia ...
Castro,Angela Potter de; Castro Junior,Miguel Angelo Martins de; Lauz,Susi; Facin,Emilio; Simões,Manuel de Jesus; Fagundes,Djalma JoséPURPOSE: To study the lesions in the lung of rabbits caused by ischemia/reperfusion hepatic (I/R) after the use of N-acetyl-cysteine (NAC). METHODS: Twenty-four rabbits distributed in two groups: control group GI (n = 12) 5% glucose solution and experiment group GII (n = 12) NAC. The animals were pre-anesthetized with 1% acepromazine maleate and anesthetized with ketamine 10% and 2% xylazine intramuscularly. Th...
Effect of N-acetylcysteine in liver ischemia-reperfusion injury after 30% hepat...
Lee,Edwin Jin Su; Silva,Sonia Maria da; Simões,Manuel de Jesus; Montero,Edna Frasson de SouzaPURPOSE: Evaluate the effect of N-acetylcysteine in liver remnant after hepatectomy associated to ischemia-reperfusion injury in mice. METHODS: Male adult BALB/c mice, weighing 20-22g were used. Animals were anesthetized with ketamine (70 mg/kg) and xylazine (10 mg/kg); received N-acetylcysteine (150 mg/kg, H-IR-NAC group) or vehicle (H-IR group). Surgical procedures were performed under 10X magnification. Part...