56 documents found, page 1 of 6
Effect of hyperbaric oxygenation on random rat skin flaps vascularization
Rech,Fabricio Valandro; Simões,Ricardo Santos; Pires,Jefferson André; Florêncio-Silva,Rinaldo; Fagundes,Djalma JoséABSTRACT Purpose: To evaluate the effect of hyperbaric oxygenation (HBO) on angiogenesis in random rat skin flaps, by immunoexpression of vascular endothelial growth factor A (VEGF-A). Methods: Forty adult rats were divided into four groups: GE) epilated; GE/HBO) epilated subjected to HBO; GER) epilated submitted to dorsal skin flap; GER/HBO) epilated subjected to dorsal skin flap + HBO. HBO was performed with ...
Imbalance between the cellular proliferation and death in harderian gland of fe...
Araújo,Ariadne Stavare Leal; Verna,Carina; Araújo Júnior,Osvaldo Pereira; Soares Júnior,José Maria; Simões,Ricardo Santos; Baracat,Edmund ChadaSUMMARY OBJECTIVE: To assess the impact of the metoclopramide-induced hyperprolactinemia in cellular death and proliferation in the harderian gland of female mice. METHODS: Twenty female mice were divided into two groups of 10 animals each and treated: 0.2 mL of saline solution (controls, Ctr) and 200 µg of metoclopramide (experimental, hyperprolactinemia), both for 50 consecutive days and at 12:00 a.m. On the ...
The influence of phytoestrogens or estrogens on the proliferation of the rat en...
Franco,Paulo Celso; Simões,Ricardo Santos; Carbonel,Adriana Aparecida Ferraz; Sasso,Gisela Rodrigues da Silva; Florencio-Silva,RinaldoSUMMARY INTRODUCTION Although estrogen therapy is widely used against post-menopausal symptoms, it can present adverse effects, including endometrial cancer. Soy isoflavones are considered a possible alternative to estrogen therapy. However, there are still concerns whether isoflavones exert trophic effects on the uterine cervix. OBJECTIVES To evaluate the histomorphometric and immunohistochemical alterations i...
Melatonin and organ transplantation: what is the relationship?
Haddad,Carolina F.; Haddad,Jorge M.; Veiga,Eduardo Carvalho de Arruda; Sorpreso,Isabel Cristina Esposito; Simões,Ricardo Santos; Baracat,Edmund ChadaSUMMARY Melatonin has anti-inflammatory and antioxidant properties that can influence tissue growth and apoptosis. This aspect may influence the success of organ transplantation. OBJECTIVE To evaluate the relationship between melatonin and organ transplantation. METHODS A systematic review was performed in PubMed databases using the search terms: “melatonin physiology” or “melatonin therapy” and “transplant pha...
Action of hormonal therapy in amyotrophic lateral sclerosis: a systematic review
Vasconcelos,Kátia de; Oliveira,Acary Souza Bulle; Fuchs,Luiz Fernando Portugal; Simões,Ricardo Santos; Simoes,Manuel de JesusSUMMARY Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by muscle weakness, atrophy, fasciculations, and decreased reflexes due to upper and lower motor neurons death. It can be present in both sexes (55-65 years), but with predominance in males. However, in female patients, ALS presents its first symptoms when they are already postmenopausal, when then the incidence ratio of the disease is...
Ointment of Ximenes americana promotes acceleration of wound healing in rats
Souza Neto Júnior,José de Castro; Estevão,Lígia Reis de Moura; Ferraz,Adriana Aparecida; Simões,Ricardo Santos; Vieira,Marcela Gabriela FeitosaAbstract Purpose: To evaluate the healing potential of the Ximenia americana hydroalcoholic extract in 10% cream in excisional wound models in rats. Methods: Sixty male adults Wistar rats were submitted to skin and subcutaneous tissue surgery in the right and left thoracic regions, divided into three experimental groups: Standard submitted to treatment with only the base vehicle, Treated wounds treated with hyd...
The role of ischemic preconditioning in the expression of apoptosis-related gen...
Miranda,Celina Teresa Castelo Branco Couto de; Fagundes,Djalma José; Miranda,Edinaldo de; Simões,Ricardo Santos; Carbonel,Adriana Aparecida FerrazAbstract Purpose: To analyze the effects of ischemic preconditioning (IPC) in the expression of apoptosis-related genes in rat small intestine subjected to ischemia and reperfusion. Methods: Thirty anesthetized rats underwent laparotomy and were drive into five groups: control (CG); ischemia (IG); ischemia and reperfusion (IRG); IPC and ischemia (IG+IPC); IPC and ischemia and reperfusion (I/RG+IPC). Intestinal ...
Melatonin may prevent or reverse polycystic ovary syndrome in rats
Lombardi,Leonardo Augusto; Mattos,Leandro Sabará de; Simões,Ricardo Santos; Florencio-Silva,Rinaldo; Sasso,Gisela Rodrigues da SilvaSUMMARY OBJECTIVE To evaluate the ovarian effects of melatonin (Mel) in a rat model of polycystic-ovary-syndrome (PCOS) before and after permanent estrus induction. METHODS Thirty-two adult-female rats with regular estrous cycle were equally divided into four groups: 1) GCtrl – at estrous phase. 2) GPCOS - at permanent-estrous phase. 3) GMel1 – treated for 60 days with Mel (0.4 mg/Kg) during permanent estrus in...
Melatonin effects on ovarian follicular cells: a systematic review
Minguini,Isabela Pasqualini; Luquetti,Camila Maganhin; Baracat,Maria Cândida Pinheiro; Maganhin,Carla Cristina; Nunes,Camila de OliveiraSUMMARY Melatonin is known for its effects on both the sleep and reproductive system of mammals. The latter has melatonin receptors type 1 and 2, which act to regulate, among other things, cyclic AMP. Notwithstanding all the literature data, there is still no sound knowledge or a clear understanding of the hormone’s action on the physiology of ovarian follicular cells. OBJECTIVE To review and evaluate studies a...
Pelvic congestion syndrome - treatment with pelvic varicose veins embolization
Almeida,Glauce Romeiro de; Silvinato,Antonio; Simões,Ricardo Santos; Buzzini,Renata Ferreira; Bernardo,Wanderley MThe Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status ...