2 documents found, page 1 of 1
Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular...
Rodrigues, Sílvia C.; Cardoso, Renato M. S.; Freire, Patricia C.; Gomes, Cláudia F.; Duarte, Filipe V.; Neves, Ricardo Pires das; Simões-Correia, JoanaUmbilical cord blood (UCB) has long been seen as a rich source of naïve cells with strong regenerative potential, likely mediated by paracrine signals. More recently, small extracellular vesicles (sEV), such as exosomes, have been shown to play essential roles in cell-to-cell communication, via the transport of numerous molecules, including small RNAs. Often explored for their potential as biomarkers, sEV are n...
E-cadherin destabilization accounts for the pathogenicity of missense mutations...
Simões-Correia, Joana; Figueiredo, Joana; Lopes, Rui; Stricher, François; Oliveira, Carla; Serrano, Luís; Seruca, RaquelE-cadherin is critical for the maintenance of tissue architecture due to its role in cell-cell adhesion. E-cadherin mutations are the genetic cause of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations represent a clinical burden, due to the uncertainty of their pathogenic role. In vitro and in vivo, most mutations lead to loss-of-function, although the causal factor is unknown for the majority. We...