2 documents found, page 1 of 1
Neuroprotective Effects of Olive Oil
Gonçalves, Marta; Vale, Nuno; Silva, PaulaUIDB/05021/2020 UIDP/05021/2020; Neurodegenerative diseases are a significant challenge to global healthcare, and oxidative stress plays a crucial role in their development. This paper presents a comprehensive analysis of the neuroprotective potential of olive oil, with a primary focus on its antioxidant properties. The chemical composition of olive oil, including key antioxidants, such as oleuropein, hydroxyty...
Coupling the antimalarial cell penetrating peptide TP10 to classical antimalari...
Aguiar, Luísa; Biosca, Arnau; Lantero, Elena; Gut, Jiri; Vale, Nuno; Rosenthal, Philip J.; Nogueira, Fátima; Andreu, David; Fernàndez-Busquets, XavierRecently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, including TP10, a cell penetrating peptide with intrinsic antiplasmodial activity. Chloroquine-TP10 conjugates displayi...