2 documents found, page 1 of 1
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVI...
Freitas, AT; Calhau, C; Antunes, G; Araújo, B; Bandeira, M; Barreira, S; Bazenga, F; Braz, S; Caldeira, D; Santos, SCR; Faria, A; Faria, D; Fraga, MVitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese populatio...
Ionizing radiation modulates human macrophages towards a pro-inflammatory pheno...
Pinto, AT; Pinto, ML; Cardoso, AP; Monteiro, C; Pinto, MT; Maia, AF; Castro, P; Figueira, R; Monteiro, A; Marques, M; Mareel, M; Santos, S; Seruca, RIn order to improve the efficacy of conventional radiotherapy, attention has been paid to immune cells, which not only modulate cancer cell response to therapy but are also highly recruited to tumours after irradiation. Particularly, the effect of ionizing radiation on macrophages, using therapeutically relevant doses, is not well understood. To evaluate how radiotherapy affects macrophage behaviour and macroph...