14 documents found, page 1 of 2
Biological properties and phytochemical characterization from Miconia chamissoi...
Gomes, Lorena Ferreira; Martins, Diegue Henrique Nascimento; Silva, Sandra Marcia Mazutti da; Barros, Yuri Yabu de; Souza, Paula Monteiro deThe objective of this study was to evaluate biological and phytochemical properties of the aqueous extract from the leaves of Miconia chamissoisNaudin (AEMC). Phytochemical properties were assessed by analyzing the chromatographic profile and the polyphenol content of AEMC. Biological properties evaluation wasconducted based on cytotoxicity assay and by evaluating the antioxidant, antimicrobial, and enzymatic i...
Influence of in vitro micropropagation on lycorine biosynthesis and anticholine...
Costa, Gabriella Gusmão Pereira da; Silva, Cristian Aldemar Gasca; Gomes, João Victor Dutra; Torres, Amanda Gomes; Santos, Izulmé Rita ImaculadaHippeastrum goianum (Ravenna) Meerow, Amaryllidaceae, is an endemic species from the Cerrado, Brazil; there are only few studies about its chemistry or biological activity. This study aimed to investigate the occurrence of lycorine in extracts from in vitro H. goianum plantlets, as well as evaluate a possible inhibition of acetylcholinesterase. The ethanol extract of plantlets produced by in vitro seed germinat...
Determination of harpagoside in Harpagophytum procumbens DC tablet’s using anal...
Ribeiro, Gislane dos Santos; Carneiro, Amanda de Assis; Martins, Diegue Henrique Nascimento; Simeoni, Luiz Alberto; Silveira, DâmarisThe species Harpagophytum procumbens DC. is popularly known as devil’s claw and is widely used because of its anti-inflammatory properties that are attributed to an iridoid glycoside, the harpagoside. This medicinal plant is part of the Brazilian List of Essential Medicines, that is, it was selected and standardized for the resolution of diseases in the Brazilian public health system, SUS, and can be found in s...
Determinação de ácido rosmarínico em Cordia verbenacea por cromatografia líquid...
Matos, D. O.; Tironi, Felipe Lipparelli; Martins, D. H. N.; Fagg, Christopher William; Netto Júnior, N. L.; Simeoni, Luiz Alberto; Magalhães, P. O.Neste estudo, uma técnica de cromatografia líquida de alta resolução em fase reversa (CLAE-FR) para a determinação de ácido rosmarínico em Cordia verbenacea foi desenvolvida e validada. A análise de regressão foi avaliada, com observação de uma boa linearidade (r = 0,9997). Os valores obtidos para a precisão e exatidão estão de acordo com as diretrizes do ICH e com a legislação brasileira. Os valores de repetib...
Thyroid hormone response element organization dictates the composition of activ...
Velasco, Lara Franciele Ribeiro; Togashi, Marie; Walfish, Paul G.; Pessanha, Rutnéia de Paula; Moura, Fanny Nascimento; Barra, Gustavo BarcelosThyroid hormone (triiodothyronine, T3) is known to activate transcription by binding heterodimers of thyroid hormone receptors (TRs) and retinoid X receptors (RXRs). RXR-TRs bind to T3 response elements (TREs) composed of direct repeats of the sequence AGGTCA spaced by four nucleotides (DR-4). In other TREs, however, the half-sites can be arranged as inverted palindromes and palindromes (Pal). Here we show that...
α-Amylase inhibitors : a review of raw material and isolated compounds from pla...
Sales, Paloma Michelle de; Souza, Paula Monteiro de; Simeoni, Luiz Alberto; Batista, Pérola de Oliveira Magalhães Dias; Silveira, DâmarisABSTRACT; Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases. Plants are an important source of chemical constituents with potential for inhibition of α-amylase and can be used as therapeutic or functional food source...
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms
Bleicher, Lucas; Aparicio, Ricardo; Nunes, Fábio Macêdo; Martínez, Leandro; Dias, Sandra Martha Gomes; Figueira, Ana Carolina MiglioriniBackground: Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Therefore, β-selective thyromimetics have been developed as promising drug-candidates for treatment of obesity and eleva...
Síntesis y estructura de espiro [pirrolidin-2,4'-piperidinas]
Kouznetsov, Vladimir; Palma Rodriguez, Alirio; Lantsetov, Sergei; Simeoni, Luiz AlbertoRESUMEN; Se estudió la formación de r,2',5'-trimetilespiro[pirrolidin-2,4'-piperidinasJ a partir de sus correspondientes l,2,5-trimetil-4-alil-4-aminopiperidinas en condiciones de la reacción de aminomercuración. Los productos formados se aislaron por cromatografía en columna sobre alúmina (ALO,) y sus estructuras se establecieron por medio del análisis espectroscópico ( IR, RMN 'H y espectrometría de masas). _...
GQ-16, a novel peroxisome proliferator-activated receptor (PPAR ) ligand, promo...
Amato, Angélica Amorim; Rajagopalan, Senapathy; Lin, Jean Z.; Carvalho, Bruno de Melo; Figueira, Ana Carolina Migliorini; Lu, Jenny; Ayers, Stephen D.ABSTRACT; Background: PPAR agonists improve insulin sensitivity but also evoke weight gain. Results: GQ-16 is a PPAR partial agonist that blocks receptor phosphorylation by Cdk5 and improves insulin sensitivity in diabetic mice in the absence of weight gain. Conclusion: The unique binding mode of GQ-16 appears to be responsible for the compound’s advantageous pharmacological profile. Significance: Similar compo...
Preparação de argila modificada com cloreto de cetilpiridíneo e avaliação da in...
Resende, Daniel Karl; Dornelas, Camila Braga; Tavares, Maria Ines Bruno; Gomes, Ailton de Souza; Moreira, Leonardo A.; Cabral, Lúcio MendesFoi preparada uma argila modificada com cloreto de cetilpiridíneo a partir da argila sódica por troca de cátions em solução. Foi avaliada a quantidade de agente de modificação em relação à argila sódica e o tempo reacional. Os materiais obtidos foram caracterizados por difração de raio X (XRD), análise termogravimétrica (TGA) e ressonância magnética nuclear (RMN) de baixo campo. Após a caracterização foi confir...