3 documents found, page 1 of 1
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex ...
Karkucinska-Wieckowska, Agnieszka; Simoes, Ines C M; Kalinowski, Piotr; Lebiedzinska-Arciszewska, Magdalena; Zieniewicz, Krzysztof; Milkiewicz, PiotrAccording to the 'multiple-hit' hypothesis, several factors can act simultaneously in nonalcoholic fatty liver disease (NAFLD) progression. Increased nitro-oxidative (nitroso-oxidative) stress may be considered one of the main contributors involved in the development and risk of NAFLD progression to nonalcoholic steatohepatitis (NASH) characterized by inflammation and fibrosis. Moreover, it has been repeatedly ...
The mystery of mitochondria-ER contact sites in physiology and pathology: A can...
Simoes, Ines C M; Morciano, Giampaolo; Lebiedzinska-Arciszewska, Magdalena; Aguiari, Gianluca; Pinton, Paolo; Potes, Yaiza; Wieckowski, Mariusz R.Mitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca2+) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors a...
Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Developmen...
Simoes, Ines C M; Karkucinska-Wieckowska, Agnieszka; Janikiewicz, Justyna; Szymanska, Sylwia; Pronicki, Maciej; Dobrzyn, Pawel; Dabrowski, MichalNonalcoholic fatty liver disease (NAFLD) is characterized by the development of steatosis, which can ultimately compromise liver function. Mitochondria are key players in obesity-induced metabolic disorders; however, the distinct role of hypercaloric diet constituents in hepatic cellular oxidative stress and metabolism is unknown. Male mice were fed either a high-fat (HF) diet, a high-sucrose (HS) diet or a com...