13 documents found, page 1 of 2
Polypharmacological strategies for infectious bacteria
Leita, MM; Gonçalves, ASC; Borges, F; Simoes, M; Anabela BorgesPolypharmacological approaches have significant potential for the treatment of various complex diseases, including infectious bacteria-related diseases. Actually, multitargeting agents can achieve better therapeutic effects and overcome the drawbacks of monotherapy. Although multidrug multitarget strategies have demonstrated the ability to inactivate infectious bacteria, several challenges have been pointed out...
Antibacterial effects of novel quaternary ammonium and phosphonium salts agains...
Nunes, B; Cagide, F; Anabela Borges; Borges, F; Simoes, MAim This study investigates the mechanisms of action of a promising series of previously synthesized quaternary ammonium (QASs) and phosphonium (QPSs) salts, which have shown potent activity against Staphylococcus aureus, including methicillin-resistant strains (MRSA).Methods and results The effects of QASs and QPSs on S. aureus surface charge, total surface hydrophobicity, intracellular potassium release, memb...
New insights on antibacterial mode of action of blue-light photoactivated berbe...
Gonsalves, ASC; Fernandes, JR; Saavedra, MJ; Guimaraes, NM; Pereira, C; Simoes, M; Anabela Borges; Simões MAntimicrobial photodynamic inactivation (aPDI), using photosensitisers in combination with antibiotics, is a promising multi-target strategy to address antibiotic resistance, particularly in wound infections. This study aimed to elucidate the antibacterial mode of action of combinations of berberine (Ber) or curcumin (Cur) with selected antibiotics (Ber-Ab or Cur-Ab) under blue light irradiation (420 nm) agains...
The ability of Salmonella enterica subsp. enterica strains to form biofilms on ...
Perez-Lavalle, L; Anabela Borges; Gomes, IB; Carrasco, E; Valero, A; Simoes, M; Simões M; Inês GomesThe ability of Salmonella enterica subsp. enterica to persist and form biofilms on different surfaces can constitute a source of food contamination, being an issue of global concern. The objective of this study was to understand the biofilm formation profile of 14 S. enterica strains among different serovars and sources and to evaluate the ability of essential oil (EO) components (carveol, citronellol, and citr...
Antimicrobial cyclodextrin-assisted electrospun fibers loaded with carvacrol, c...
Gonzalez-Prada, I; Anabela Borges; Santos-Torres, B; Magariños, B; Simoes, M; Concheiro, A; Alvarez-Lorenzo, C; Simões MThis work aimed to explore an alternative to the use of antibiotics for prevention and treatment of wounds infection caused by two common bacterial pathogens Staphylococcus aureus and Pseudomonas aeruginosa. For this purpose, three different essential oil components (EOCs), namely carvacrol, citronellol and cinnamic acid, were loaded into electrospun fibers of poly-epsilon-caprolactone (PCL) aided by alpha-cycl...
Efficacy of Novel Quaternary Ammonium and Phosphonium Salts Differing in Cation...
Nunes, B; Cagide, F; Fernandes, C; Anabela Borges; Fernanda Borges; Simoes, M; Simões MAntibacterial resistance poses a critical public health threat, challenging the prevention and treatment of bacterial infections. The search for innovative antibacterial agents has spurred significant interest in quaternary heteronium salts (QHSs), such as quaternary ammonium and phosphonium compounds as potential candidates. In this study, a library of 49 structurally related QHSs was synthesized, varying the ...
Dual action of benzaldehydes: Inhibiting quorum sensing and enhancing antibioti...
Leitao, MM; Vieira, TF; Sousa, SF; Fernanda Borges; Simoes, M; Anabela Borges; Simões MQuorum sensing (QS) has a central role in biofilm lifestyle and antimicrobial resistance, and disrupting these signaling pathways is a promising strategy to control bacterial pathogenicity and virulence. In this study, the efficacy of three structurally related benzaldehydes (4-hydroxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde (vanillin) and 4-hydroxy-3,5-dimethoxybenzaldehyde (syringaldehyde)) in disrupting...
Montelukast and cefoperazone act as antiquorum sensing and antibiofilm agents a...
Vieira, TF; Leitao, MM; Cerqueira, NMFSA; Sousa, SF; Anabela Borges; Simoes, M; Simões MAims Drug repurposing is an attractive strategy to control biofilm-related infectious diseases. In this study, two drugs (montelukast and cefoperazone) with well-established therapeutic applications were tested on Pseudomonas aeruginosa quorum sensing (QS) inhibition and biofilm control.Methods and results The activity of montelukast and cefoperazone was evaluated for Pqs signal inhibition, pyocyanin synthesis,...
Photodynamic activation of phytochemical-antibiotic combinations for combatting...
Gonçalves, ASC; Leitao, MM; Fernandes, JR; Saavedra, MJ; Pereira, C; Simoes, M; Anabela Borges; Simões MStaphylococcus aureus is characterized by its high resistance to conventional antibiotics, particularly methicillinresistant (MRSA) strains, making it a predominant pathogen in acute and chronic wound infections. The persistence of acute S. aureus wound infections poses a threat by increasing the incidence of their chronicity. This study investigated the potential of photodynamic activation using phytochemical-...
Quorum sensing architecture network in Escherichia coli virulence and pathogenesis
Mayer, C; Anabela Borges; Flament Simon, SC; Simoes, MEscherichia coli is a Gram-negative commensal bacterium of the normal microbiota of humans and animals. However, several E. coli strains are opportunistic pathogens responsible for severe bacterial infections, including gastrointestinal and urinary tract infections. Due to the emergence of multidrug-resistant serotypes that can cause a wide spectrum of diseases, E. coli is considered one of the most troublesome...