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Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-...

Leitão, Maria João; Baldeiras, Inês; Herukka, Sanna-Kaisa; Pikkarainen, Maria; Leinonen, Ville; Simonsen, Anja Hviid; Perret-Liaudet, Armand

Introduction: Core cerebrospinal fluid (CSF) biomarkers – Aβ42, Tau, and phosphorylated Tau (pTau) – have been recently incorporated in the revised criteria for Alzheimer’s disease (AD). However, their widespread clinical application lacks standardization. Preanalytical sample handling and storage play an important role in the reliable measurement of these biomarkers across laboratories. Aim: In this study, we ...


The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies o...

Reijs, Babette L R; Teunissen, Charlotte E; Goncharenko, Nikolai; Betsou, Fay; Blennow, Kaj; Baldeiras, Inês; Brosseron, Frederic; Cavedo, Enrica

Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was...


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