5 documents found, page 1 of 1
Global Prevalence of Aspirin Use for Primary Prevention of Cardiovascular Disea...
Yoo, SGK; Chung, GS; Bahendeka, SK; Sibai, AM; Damasceno, A; Farzadfar, F; Rohloff, P; Houehanou, C; Norov, B; Karki, KB; Azangoukhyavy, M; Marcus, METhe role of aspirin in the primary prevention of atherosclerotic cardiovascular disease (CVD) is not clear, with recent clinical trials evaluating aspirin for primary prevention demonstrating both modest benefits and risks associated with its use [1]. Aspirin is not routinely recommended for primary prevention of CVD. Understanding patterns of aspirin use can inform strategies to promote guideline-concordant th...
Comparison of Cardiovascular Health Profiles Across Population Surveys From 5 H...
Ware, L; Vermeulen, B; Maposa, I; Flood, D; Brant, LCC; Khandelwal, S; Singh, K; Soares, S; Jessen, N; Perman, G; Riaz, BK; Sachdev, HS; Allen, NBBackground: To facilitate the shift from risk-factor management to primordial prevention of cardiovascular disease, the American Heart Association developed guidelines to score and track cardiovascular health (CVH). How the prevalence and trajectories of a high level of CVH across the life course compare among high- and lower-income countries is unknown. Methods: Nationally representative survey data with CVH v...
Comparison of cardiovascular health profiles across population surveys from fiv...
Ware, L; Vermeulen, B; Maposa, I; Floo, D; Brant, LC; Khandelwal, S; Singh, K; Soares, S; Jessen, N; Perman, G; Riaz, BK; Sachdev, HS; Allen, NBAims With the greatest burden of cardiovascular disease morbidity and mortality increasingly observed in lower-income countries least prepared for this epidemic, focus is widening from risk factor management alone to primordial prevention to maintain high levels of cardiovascular health (CVH) across the life course. To facilitate this, the American Heart Association (AHA) developed CVH scoring guidelines to eva...
Aspirin for Secondary Prevention of Cardiovascular Disease in 51 Low-, Middle-,...
Yoo, SGK; Chung, GS; Bahendeka, SK; Sibai, AM; Damasceno, A; Farzadfar, F; Rohloff, P; Houehanou, C; Norov, B; Karki, KB; Azangou-Khyavy, M; Marcus, ME"Importance Aspirin is an effective and low-cost option for reducing atherosclerotic cardiovascular disease (CVD) events and improving mortality rates among individuals with established CVD. To guide efforts to mitigate the global CVD burden, there is a need to understand current levels of aspirin use for secondary prevention of CVD. Objective To report and evaluate aspirin use for secondary prevention of CVD a...
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-...
Yshii, L; Pasciuto, E; Bielefeld, P; Mascali, L; Lemaitre, P; Marino, M; Dooley, J; Kouser, L; Verschoren, S; Lagou, V; Kemps, H; Gervois, P; Boer, AThe ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification of both effective targets for local immune modulation and a delivery system capable of crossing the blood-brain barrier. The recent identification and characterization of a small population of regulatory T (Treg) cells...