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Global age-sex-specific mortality, life expectancy, and population estimates in...

Schumacher, AE; Kyu, HH; Aali, A; Abbafati, C; Abbas, J; Abbasgholizadeh, R; Abbasi, MA; Abbasian, M; Abd ElHafeez, S; Abdelmasseh, M; Abd Elsalam, S

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides n...


Mapping inequalities in exclusive breastfeeding in low- and middle-income count...

Bhattacharjee, NV; Schaeffer, LE; Hay, SI; Lu, D; Schipp, MF; Lazzar-Atwood, A; Donkers, KM; Abady, GG; Abd-Allah, F; Abdelalim, A; Abebo, ZH

Exclusive breastfeeding (EBF)-giving infants only breast-milk for the first 6 months of life-is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (LMICs) are required for planning policy and interventions. Here w...


Sulforaphane prevents age-associated cardiac and muscular dysfunction through N...

Bose, C; Alves, I; Singh, P; Palade, PT; Carvalho, E; Børsheim, E; Jun, SR; Cheema, A; Boerma, M; Awasthi, S; Singh, SP

Age-associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia and cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial properties in both sarcopenia and CVD. Sulforaphane (SFN), a natural compound Nrf2-related act...


Five-Year Review of an International Clinical Research-Training Program

Suemoto, C; Ismail, S; Corrêa, P; Khawaja, F; Jerves, T; Pesantez, L; Germani, AC; Zaina, F; Junior, A; Ferreira, R; Singh, P; Paulo, J; Matsubayashi, S

The exponential increase in clinical research has profoundly changed medical sciences. Evidence that has accumulated in the past three decades from clinical trials has led to the proposal that clinical care should not be based solely on clinical expertise and patient values, and should integrate robust data from systematic research. As a consequence, clinical research has become more complex and methods have be...


Five-year review of an international clinical research-training program

Suemoto, CK; Ismail, S; Corrêa, PC; Khawaja, F; Jerves, T; Pesantez, L; Germani, AC; Zaina, F; Soares dos Santos, AC; Oliveira-Ferreira, RJ; Singh, P

The exponential increase in clinical research has profoundly changed medical sciences. Evidence that has accumulated in the past three decades from clinical trials has led to the proposal that clinical care should not be based solely on clinical expertise and patient values, and should integrate robust data from systematic research. As a consequence, clinical research has become more complex and methods have be...


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