4 documents found, page 1 of 1
Synergic effect of allopurinol in combination with nitro-heterocyclic compounds...
Mazzeti, Ana Lia; Diniz, Lívia de Figueiredo; Gonçalves, Karolina Ribeiro; WonDollinger, Ruan Schott; Martins, Tassiane Assíria Fontes; Ribeiro, IsabelaCombination therapy has gained attention as a possible strategy for overcoming the limitations of the present therapeutic arsenal for Chagas disease. The aim of this study was to evaluate the effect of allopurinol in association with nitroheterocyclic compounds on infection with the Y strain of Trypanosoma cruzi. The in vitro effect of allopurinol plus benznidazole or nifurtimox on intracellular amastigotes in ...
Benznidazole and Posaconazole in experimental Chagas disease: positive interact...
Diniz, Lívia de Figueiredo; Urbina, Julio Alberto; Andrade, Isabel Mayer de; Mazzeti, Ana Lia; Martins, Tassiane Assíria Fontes; Caldas, Ivo SantanaBackground: Current chemotherapy for Chagas disease is unsatisfactory due to its limited efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment discontinuation. Combined therapy is envisioned as an ideal approach since it may improve treatment efficacy whilst decreasing toxicity and the likelihood of resistance development. We evaluated the efficacy of posaconazole in...
Fexinidazole : a potential new drug candidate for Chagas disease.
Bahia, Maria Terezinha; Andrade, Isabel Mayer de; Martins, Tassiane Assíria Fontes; Nascimento, Álvaro Fernando da Silva do; Diniz, Lívia de FigueiredoBackground: New safe and effective treatments for Chagas disease (CD) are urgently needed. Current chemotherapy options for CD have significant limitations, including failure to uniformly achieve parasitological cure or prevent the chronic phase of CD, and safety and tolerability concerns. Fexinidazole, a 2-subsituted 5-nitroimidazole drug candidate rediscovered following extensive compound mining by the Drugs ...
Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in exp...
Santos, Daniela Maria dos; Martins, Tassiane Assíria Fontes; Caldas, Ivo Santana; Diniz, Lívia de Figueiredo; Coelho, George Luiz Lins MachadoThe factors involved in the reactivation of chronic Chagas disease infection are not clear enough and may be related to host immune unbalance and/or parasite genetic diversity. To evaluate the role of the Trypanosoma cruzi genetic background in the Chagas disease reactivation, we inoculated Cyclophosphamide-immunos upressed (CyI) Swiss mice with clonal stocks from T. cruzi I (Cuica cl1, P209 cl1, Gamba cl1, SP1...