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Ozone-related acute excess mortality projected to increase in the absence of cl...

Domingo, NGG; Fiore, AM; Lamarque, J-F; Kinney, PL; Jiang, L; Gasparrini, A; Breitner, S; Lavigne, E; Madureira, J; Masselot, P; Silva, SDNPD

Short-term exposure to ground-level ozone in cities is associated with increased mortality and is expected to worsen with climate and emission changes. However, no study has yet comprehensively assessed future ozone-related acute mortality across diverse geographic areas, various climate scenarios, and using CMIP6 multi-model ensembles, limiting our knowledge on future changes in global ozone-related acute mort...


Air pollution mixture complexity and its effect on PM2.5-related mortality: A m...

Masselot, P; Kan, H; Kharol, SK; Bell, ML; Sera, F; Lavigne, E; Breitner, S; Das Neves Pereira Da Silva, S; Burnett, RT; Gasparrini, A; Brook, JR

Background: Fine particulate matter (PM2.5) occurs within a mixture of other pollutant gases that interact and impact its composition and toxicity. To characterize the local toxicity of PM2.5, it is useful to have an index that accounts for the whole pollutant mix, including gaseous pollutants. We consider a recently proposed pollutant mixture complexity index (PMCI) to evaluate to which extent it relates to PM...


Temporal variations in the short-term effects of ambient air pollution on cardi...

Schwarz, M; Peters, A; Stafoggia, M; de'Donato, F; Sera, F; Bell, ML; Guo, Y; Honda, Y; Huber, V; Jaakkola, JJK; Urban, A; Vicedo-Cabrera, AM

Background: Ambient air pollution, including particulate matter (such as PM10 and PM2·5) and nitrogen dioxide (NO2), has been linked to increases in mortality. Whether populations’ vulnerability to these pollutants has changed over time is unclear, and studies on this topic do not include multicountry analysis. We evaluated whether changes in exposure to air pollutants were associated with changes in mortality ...


Joint effect of heat and air pollution on mortality in 620 cities of 36 countries

Stafoggia, M; Michelozzi, P; Schneider, A; Armstrong, B; Scortichini, M; Rai, M; Achilleos, S; Alahmad, B; Analitis, A; Åström, C; Bell, ML; Calleja, N

Background The epidemiological evidence on the interaction between heat and ambient air pollution on mortality is still inconsistent. Objectives To investigate the interaction between heat and ambient air pollution on daily mortality in a large dataset of 620 cities from 36 countries. Methods We used daily data on all-cause mortality, air temperature, particulate matter ≤ 10 μm (PM10), PM ≤ 2.5 μm (PM2.5), nitr...


Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

Liu, C; Cai, J; Chen, R; Sera, F; Guo, Y; Tong, S; Li, S; Lavigne, E; Correa, PM; Ortega, NV; Orru, H; Maasikmets, M; Jaakkola, JJK; Ryti, N

Rationale: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data ...


Differential Mortality Risks Associated With PM2.5 Components A Multi-Country, ...

Masselot, P; Sera, F; Schneider, R; Kan, H; Lavigne, É; Stafoggia, M; Tobias, A; Chen, H; Burnett, RT; Schwartz, J; Zanobetti, A; Bell, ML; Chen, B-Y

Background: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. Methods: We applied a 2-stage analysis on data collected from 210 locations in 16 countries. In the first stag...


Short term associations of ambient nitrogen dioxide with daily total, cardiovas...

Meng, X; Liu, C; Chen, R; Sera, F; Vicedo-Cabrera, AM; Milojevic, A; Guo, Y; Tong, S; Coelho, MSZS; Saldiva, PHN; Lavigne, E; Correa, PM; Ortega, NV

Objective To evaluate the short term associations between nitrogen dioxide (NO2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. Design Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. Setting 398 cities in 22 low to high income countries/regions. Main outcome measure...


Mortality risk attributable to wildfire-related PM(2·5) pollution: a global tim...

Chen, G; Guo, Y; Yue, X; Tong, S; Gasparrini, A; Bell, ML; Armstrong, B; Schwartz, J; Jaakkola, JJK; Zanobetti, A; Lavigne, E; Nascimento Saldiva, PH

Background Many regions of the world are now facing more frequent and unprecedentedly large wildfires. However, the association between wildfire-related PM2·5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2·5 and mortality across various regions of the world. Methods For this time series study, data on daily co...


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