15 documents found, page 1 of 2
Subconjunctival adalimumab for treatment of dry eye disease in Sjögren’s syndrome
Vargas,Juliana Ferreira da Costa; Skare,Thelma; Gehlen,Marcelo Luiz; Moreira,Ana Tereza RamosABSTRACT Objective To describe the use of subconjuctival administration of the anti-tumor necrosis factor agent adalimumab for treatment of dry eye in patients with Sjögren’s syndrome, and to investigate conjunctival healing. Methods Prospective, nonrandomized, noncomparative interventional case series including consecutive patients with Sjögren’s syndrome and dry eye disease treated with subconjunctival adalim...
Quality of life in children and adults with Idiopathic juvenile arthritis: cros...
Lourenço,Elora Sampaio; Lourenço,Cibele; Skare,Thelma; Spelling,Paulo; Nisihara,RenatoABSTRACT BACKGROUND AND OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease which may persist into adulthood. Pain and joint deformities affect quality of life (QoL). The objective was to study the influence of JIA in QoL of children and adults, comparing the two groups. METHODS: Cross-sectional study of 47 JIA patients (20 children and 27 adults) using the following questionnaires: J...
Isotretinoin, Acne and Depression: A Prospective Controlled Study
Langer,Laura V; Prim,Lucas; Skare,Thelma; Wrublevski,Virginia X; Nisihara,RenatoABSTRACT Introduction: Acne and isotretinoin, one of its treatment, have been linked to the occurrence of depression. Our aim was to study if isotretinoin is associated with depression in a sample of acne patients followed for 6 months comparing them with acne patients under other treatment modalities and control patients without acne. Methods: One hundred individuals were included: 50 controls and 50 with acne...
Dry eye in systemic lupus erythematosus patients
Goginski,Julia; Gonçalves,Lucas Augusto Prestes; Neppel,Aline; Lemes,Macleise Andres; Longo,Sabrina; Furlan,Fernanda; Skare,ThelmaAbstract Objective: To study the association of dry eye with lupus disease activity and cumulative damage. To verify if epidemiological, treatment and autoantibody profile of SLE (systemic Lupus erythematosus) patients influence the presence of dry eye. Methods: We studied 70 SLE patients for the presence of dry eye by Schirmer test, disease activity by SLEDAI (SLE-Disease activity index) and cumulative damage ...
Risk factors for new-onset diabetes mellitus after kidney transplantation (NODA...
Lima,Camila; Grden,Amanda; Skare,Thelma; Jaworski,Paulo; Nisihara,RenatoABSTRACT Objectives: This study aims to verify the new-onset diabetes after kidney transplant (NODAT) incidence in recipients within 1 year after kidney transplantation from a single center in Southern Brazil and to assess the associated conditions. Subjects and methods: A retrospective study of 258 post-renal transplant patients was performed. Demographic (gender, age, ethnic background) and clinical (origin o...
Evaluation of foot functionality in cases of rheumatoid arthritis through the F...
Inoue,Elinah Narumi; Andrade,Agnes Patricia de; Skare,ThelmaABSTRACT BACKGROUND: Rheumatoid arthritis (RA) can affect the feet, thus compromising the patient’s gait and autonomy. In this study, we investigated foot disability in RA patients using the Brazilian versions of the Foot Health Status Questionnaire (FHSQ-BR) and Foot Function Index (FFI-BR). DESIGN AND SETTING: Cross-sectional, observational study conducted in a tertiary care hospital. METHODS: Two hundred ind...
Erectile dysfunction in ankylosing spondylitis patients
Santana,Thiago; Skare,Thelma; Delboni,Vitor Steil; Simione,Juliana; Campos,Ana Paula B.; Nisihara,RenatoABSTRACT Background Rheumatic diseases such as ankylosing spondylitis (AS) may be associated with sexual dysfunction. Aim To study erectile function of a group of Brazilian AS patients comparing them with controls. Materials and Methods This was a cross sectional study approved by the local Committee of Ethics in Research. The questionnaire IIEF (International Index of Erectile Function) was applied to 40 AS pa...
Prevalence of the American College of Rheumatology hematological classification ...
Skare,Thelma; Damin,Renata; Hofius,RenataObjective: To study systemic lupus erythematosus in a Brazilian population using the American College of Rheumatology hematological classification criteria and report associations of the disease with serological and clinical profiles. Methods: This is a retrospective study of 460 systemic lupus erythematosus patients followed in a single rheumatologic center during the last 10 years. Hematological manifestations ...
Tradução e validação do índice da doença da superfície ocular para a língua por...
Prigol,Adriano Mauricio; Tenório,Marília Barreto; Matschinske,Roberta; Gehlen,Marcelo Luiz; Skare,ThelmaOBJETIVO: Desenvolver uma versão transcultural do "ocular surface disease index" (OSDI) para a população brasileira e analisar sua validade e eficácia. MÉTODOS: Baseados nas orientações de Guillemin et al. Foram convidados 4 professores de inglês, 1 médico oftalmologista, 1 médica reumatologista, 2 residentes de oftalmologia e 1 nativo-americano que não fala o português. O procedimento seguiu as etapas: traduçã...
Avaliação da espessura do complexo médio-intimal da artéria carótida como marca...
Macedo,Rodrigo; Andretta,Marianne; Albers,Carolina; Skare,Thelma; Ribas-Filho,Jurandir Marcondes; Czeczko,Nicolau GregoriOBJETIVO: Avaliar a espessura da camada médio-intimal da artéria carótida comum em pacientes com e sem esclerodermia e verificar possível associação com sua gravidade. MÉTODOS: Em estudo caso-controle, foram selecionados 30 pacientes com esclerodermia e 30 sem a doença e pareados de acordo com a idade, sexo, hipertensão arterial sistêmica, diabete melito e hipercolesterolemia. Todos os pacientes foram submetido...