3 documents found, page 1 of 1
Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein-pepti...
Inostroza-Brito, K. E.; Collin, E.; Siton-Mendelson, O.; Smith, K. H.; Monge-Marcet, A.; Ferreira, D. S.; Rodríguez, R. P.; Alonso, M.Controlling molecular interactions between bioinspired molecules can enable the development of new materials with higher complexity and innovative properties. Here we report on a dynamic system that emerges from the conformational modification of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be maintained in, non-equilibrium for substantial periods of time. The system enabl...
Co-assembled and microfabricated bioactive membranes
Mendes, A. C.; Smith, K. H.; Tejeda-Montes, E.; Engel, E.; Reis, R. L.; Azevedo, Helena S.; Mata, A.The fabrication of hierarchical and bioactive self-supporting membranes, which integrate physical and biomolecular elements, using a single-step process that combines molecular self-assembly with soft lithography is reported. A positively charged multidomain peptide (with or without the cell-adhesive sequence arginine-glycine-aspartic acid-serine (RGDS)) self-assembles with hyaluronic acid (HA), an anionic biop...
Spontaneous co-assembly of molecularly designed building blocks into hierarchic...
Smith, K. H.; Inostroza, K. E.; Alonso, Matilde; Reis, R. L.; Azevedo, Helena S.; Mata, A.A major limitation in generating materials using bottom-up strategies is the lack of order at the macroscale. In this work, we show that two self-assembling molecules, an elastin-like polymer (ELP) and a peptide amphiphile (PA), can interact to spontaneously to form hierarchically ordered, dynamic, bioactive, macrotubes. An RGD-containing ELP and a PA (C16V3A3K3) were synthesised using standard methods. The add...