4 documents found, page 1 of 1
Deregulated expression of SRC, LYN and CKB kinases by DNA methylation and its p...
Mello, Adriano Azevedo; Leal, Mariana Ferreira; Rey, Juan Antonio; Pinto, Giovanny Rebouças; Lamarão, Leticia Martins; Montenegro, Raquel CarvalhoKinases are downstream modulators and effectors of several cellular signaling cascades and play key roles in the development of neoplastic disease. In this study, we aimed to evaluate SRC, LYN and CKB protein and mRNA expression, as well as their promoter methylation, in gastric cancer. We found elevated expression of SRC and LYN kinase mRNA and protein but decreased levels of CKB kinase, alterations that may h...
The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene ...
Cohen, Carina; Leal, Mariana Ferreira; Belangero, Paulo Santoro; Figueiredo, Eduardo Antônio; Smith, Marília Cardoso; Andreoli, Carlos VicenteOBJECTIVES: We evaluated mRNA expression levels of genes that encode TGF-β1; the TGF-β1 receptor; the collagen-modifying enzymes LOX, PLOD1, and PLOD2; and the extracellular matrix proteins COMP, FN1, TNC and TNXB in synovial/capsule specimens from patients with idiopathic adhesive capsulitis. Possible associations between the measured mRNA levels and clinical parameters were also investigated. METHODS: We obta...
Deregulated expression of Nucleophosmin 1 in gastric cancer and its clinicopath...
Smith, Marília Cardoso
Occurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopi...
Souza, Carolina Rosal Teixeira de; Oliveira, Kátia Soares de; Ferraz, Jefferson José Sodré; Leal, Mariana Ferreira; Calcagno, Danielle QueirozBackground: Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA+ and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE). Methods: Samples from UE and GC were collected to investigate the presence of HP infection and the HP virulence factor CagA ...