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Chemical characterization of postindustrial recycled polyethylene terephthalate...
Daras, Isabela F. A.; Singh, Srishti; Vieira, Tiago; Pereira, Joel; Guerreiro, Patrícia; Sousa, Clara; Poças, FátimaTrays made from thermoformed plastic sheets represent the second major application of PET packaging after beverage bottles. PET recycling is promoted in the European Union, where ambitious targets for recycling rates and recycled content in packaging have already been established. However, PET trays, contrary to most beverage bottles, pose recycling challenges due to multilayer structures with polyethylene (PE)...
MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile
Jacinto, Sandra; Guerreiro, Patrícia; Oliveira, Rita Machado de; Oliveira, Teresa Cunha; Santos, Maria João; Grazina, Manuela; Rego, A. CristinaMutations in the MPV17 gene are associated with hepatocerebral form of mitochondrial depletion syndrome. The mechanisms through which MPV17 mutations cause respiratory chain dysfunction and mtDNA depletion is still unclear. The MPV17 gene encodes an inner membrane mitochondrial protein that was recently described to function as a non-selective channel. Although its exact function is unknown, it is thought to be...
MPV17 mutations are associated with a quiescent energetic metabolic profile
Jacinto, Sandra; Guerreiro, Patrícia; de Oliveira, Rita Machado; Cunha-Oliveira, Teresa; Santos, Maria João; Grazina, Manuela; Rego, Ana CristinaMutations in the MPV17 gene are associated with hepatocerebral form of mitochondrial depletion syndrome. The mechanisms through which MPV17 mutations cause respiratory chain dysfunction and mtDNA depletion is still unclear. The MPV17 gene encodes an inner membrane mitochondrial protein that was recently described to function as a non-selective channel. Although its exact function is unknown, it is thought to be...
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in...
de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, FrancescaSirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin 2 and α-synucl...
Mutant A53T α-synuclein improves rotarod performance before motor deficits and ...
Guerreiro, Patrícia; Coelho, Joana E; Sousa-Lima, Inês; Macedo, Paula; Lopes, Luisa V.; Outeiro, Tiago; Faria Pais, TeresaThe protein α-synuclein (α-Syn) interferes with glucose and lipid uptake and also activates innate immune cells. However, it remains unclear whether α-Syn or its familial mutant forms contribute to metabolic alterations and inflammation in synucleinopathies, such as Parkinson's disease (PD). Here, we address this issue in transgenic mice for the mutant A53T human α-Syn (α-SynA53T), a mouse model of synucleinopa...
The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusion...
Chutna, Oldriska; Goncalves, Susana; Villar-Pique, Anna; Guerreiro, Patrícia; Marijanovic, Zrinka; Mendes, Tiago; Ramalho, JoséAlpha-synuclein (aSyn) misfolding and aggregation are pathological features common to several neurodegenerative diseases, including Parkinson's disease (PD). Mounting evidence suggests that aSyn can be secreted and transferred from cell to cell, participating in the propagation and spreading of pathological events. Rab11, a small GTPase, is an important regulator in both endocytic and secretory pathways. Here, ...
Systematic comparison of the effects of Alpha-synuclein mutations on its oligom...
Lázaro, Diana F.; Rodrigues, Eva F.; Langohr, Ramona; Shahpasandzadeh, Hedieh; Ribeiro, Thales; Guerreiro, Patrícia; Gerhardt, EllenAggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic forms of PD, suggesting this protein plays a central role in the disease. However, the precise contribution of ASYN to neuronal dysfunction and death is u...
Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impa...
Diógenes, Maria José; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente; Maiolino, Francesca; Guerreiro, Patrícia; Näsström, ThomasParkinson’s disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of -synuclein (a-syn) in various brain regions is themajorpathological hallmark. Indeed, themotorsymptomsinPDare causedby a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of the brain. In a...
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impa...
Diógenes, Maria José; Dias, Raquel Baptista; Rombo, Diogo M.; Vicente Miranda, Hugo; Maiolino, Francesca; Guerreiro, Patrícia; Nasstrom, ThomasParkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are caused by a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of the br...
Behavioral and olfactory responses of female Salaria pavo (Pisces : Blenniidae)...
Serrano, Rui M.; Barata, E. N.; Birkett, Michael A.; Hubbard, Peter; Guerreiro, Patrícia; Canario, Adelino V. M.The peacock blenny, Salaria pavo (Risso 1810), typically breeds in rocky shores of the Mediterranean and adjacent Atlantic coast. Males defend a territory around a hole or cavity wherein females deposit eggs that the male guards until hatching. A pair of exocrine glands on the anal fin (anal glands) of males produces a putative pheromone involved in attraction of reproductively competent females to the nest. We...