3 documents found, page 1 of 1
Interleukin-7 receptor α mutational activation can initiate precursor B-cell ac...
Almeida, Afonso R.M.; Neto, João L.; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta B.; Raposo, BeatrizInterleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, establishes a pre-leukemic stage in which B-cell precursors display self-renewal a...
Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-relate...
Correia Guedes, Leonor; Reimão, Sofia; Paulino, Patrícia; Nunes, Rita G.; Bouça-Machado, Raquel; Abreu, Daisy; Gonçalves, Nilza; Soares, Tiago
Posttranslational modifications of blood-derived alpha-synuclein as biochemical...
Miranda, Hugo Vicente; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; Coelho, MiguelWe are thankful to the patients and participants for their kind participation and donation of samples. This study was supported by Fundacao para a Ciencia e Tecnologia (FCT) EXPL/NEU-OSD/0606/2012, PTDC/NEUOSD/5644/2014. Authors were supported by: HVM (FCT, SFRH/BPD/64702/2009, SFRH/BPD/109347/2015); MG (FCT, EXPL/NEU-OSD/0606/2012); TFO (DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain...