4 documents found, page 1 of 1
Late Holocene natural and man induced environmental changes in Western Iberian ...
Ramos Pereira, A.; Ramos, C.; Danielsen, R.; Trindade, J.; Soares, A.M.; Granja, H.; Martins, J.M.M.; Torres, A.; Araújo-Gomes, J.The Western coast of the Iberian Peninsula stands as an interface between both the Atlantic and Mediterranean climatic influences and marine / fluvial conditions. The paper aims to assess the environmental changes in the last ca 6000 years (both natural and anthropogenic induced) using multiproxy analysis (geomorphological and sedimentological data, elemental and stable isotope content, microfossil assemblages,...
Impact of acute undernutrition on growth, ileal morphology and nutrient transpo...
Sampaio, I.C.; Medeiros, P.H.Q.S.; Rodrigues, F.A.P.; Cavalcante, P.A.; Ribeiro, S.A.; Oliveira, J.S.; Prata, M.M.G.; Costa, D.V.S.; Fonseca, S.G.C.Undernutrition represents a major public health challenge for middle- and low-income countries. This study aimed to evaluate whether a multideficient Northeast Brazil regional basic diet (RBD) induces acute morphological and functional changes in the ileum of mice. Swiss mice (∼25 g) were allocated into two groups: i) control mice were fed a standard diet and II) undernourished mice were fed the RBD. After 7 da...
Synthesis and evaluation of sesquiterpene lactone inhibitors of phospholipase A...
Alvarenga, E.S. de; Silva, S.A.; Barosa, L.C.A.; Demuner, A.J.; Parreira, A.G.; Ribeiro, R.I.M.A.; Marcussi, S.; Ferreira, J.M.S.; Resende, R.R.Several sesquiterpene lactone were synthesized and their inhibitive activities on phospholipase A2 (PLA2) from Bothrops jararacussu venom were evaluated. Compounds Lac01 and Lac02 were efficient against PLA2 edema-inducing, enzymatic and myotoxic activities and it reduces around 85% of myotoxicity and around 70% of edema-inducing activity. Lac05–Lac08 presented lower efficiency in inhibiting the biological acti...
Genotoxic effect of transplacental exposure to tobacco smoke
Alves, A.C.; Costa, C.; Tirsina, A.; Monteiro, M.S.; Soares, A.M.; Loureiro, S.; Teixeira, J.P.The effect of transplacental exposure to environmental pollutants in birth outcomes has been a matter of interest to the scientific community for several years. In the past, some studies have been carried out assessing biomarkers of early effect, such as DNA adducts, micronuclei, DNA damage and more recently, epigenetic alterations. Herein, the main goal was to analyse the possible effect of mother tobacco smok...