73 documents found, page 1 of 8
Destination Branding through Tourism Entrepreneurship and Territorial Identity:...
Moura, Andreia; Morais, João; Mira, Maria Rosário; Ferreira, Ana CristinaPurpose: This study explores how entrepreneurs perceive the territorial brand of the Center Region of Portugal and identifies key attributes that influence investment decisions. A strong territorial brand enhances destination value, fostering a sense of belonging and attracting tourists, residents, and businesses.Design/methodology/approach: A transversal and exploratory study was conducted using a self-adminis...
Marketing de Moda Sustentável: Tendências, Práticas e Desafios — Uma Revisão S...
Morais, João; Leandro, AlexandraO presente estudo explora os principais temas de investigação em marketing de moda sustentável, analisando tendências, desafios e práticas identificados na literatura científica recente. A crescente consciencialização ambiental e social tem impulsionado a transição do setor da moda para modelos de negócio mais ecológicos, exigindo novas abordagens de marketing que conciliem rentabilidade e responsabilidade “ver...
A first-in-class inhibitor of homologous recombination DNA repair counteracts t...
Calheiros, Juliana; Silva, Rita; Barbosa, Filipa; Morais, João; Moura, Sara Reis; Almeida, Sofia; Fiorini, Elena; Mulhovo, Silva; Aguiar, Tatiana QuintaBackground Pancreatic ductal adenocarcinoma (PDAC) is among the cancer types with poorest prognosis and survival rates primarily due to resistance to standard-of-care therapies, including gemcitabine (GEM) and olaparib. Particularly, wild-type (wt)BRCA tumours, the most prevalent in PDAC, are more resistant to DNA-targeting agents like olaparib, restraining their clinical application. Recently, we disclosed a m...
Antithrombotic therapy after stent implantation. One size does not fit all
Morais, JoãoThe study published by Baptista et al.1 sought to assess the quality of antithrombotic therapy in a group of 996 patients with diabetes prior to coronary percutaneous intervention, searching for how guidelines are being applied in a realworld setting.
Coronary septic embolism presenting as acute myocardial infarction. A case repo...
Carvalho, Mariana Ferreira; Gonçalves, Carolina; Santos, Beatriz Saldanha; Morais, JoãoBackground Acute ST-elevation myocardial infarction (STEMI) complicated by infective endocarditis (IE) presents a unique challenge in clinical management, especially when associated with septic embolism leading to coronary artery occlusion. Case summary The current clinical report describes the case of a 72-year-old male with a history of arterial hypertension, dyslipidaemia, and severe obstructive sleep apnea....
New pharmacological agents and novel cardiovascular pharmacotherapy strategies ...
Tamargo, Juan; Agewall, Stefan; Ambrosio, Giuseppe; Borghi, Claudio; Cerbai, Elisabetta; Dan, Gheorghe A; Drexel, Heinz; Ferdinandy, PéterDespite substantial advances in cardiovascular pharmacotherapy and devices in recent years, prevention and treatment of many cardiovascular diseases (CVDs) remain limited, thus reflecting the need for more effective and safer pharmacological strategies. In this review, we summarize the most relevant studies in cardiovascular pharmacotherapy in 2024, including the approval of first-in-class drugs for the treatme...
Cardiovascular involvement in Sweet’s syndrome: A practical review
Cabral, Margarida; Santos, Luís Graça; Ruivo, Catarina; Morais, JoãoSweet’s syndrome, also referred to as acute febrile neutrophilic dermatosis, presents a constellation of clinical features including fever, tender erythematous skin lesions, peripheral neutrophilia, and a predominant dermal infiltrate of neutrophils. This uncommon condition may arise through drug-induced mechanisms, as a secondary condition to malignant diseases, or idiopathically. Importantly, extracutaneous m...
The fascinating world of clinical registries. Insights into current practice
Morais, JoãoRegistries are an important piece in building the pyramid of evidence, with multicenter randomized clinical trials at the top of that pyramid. Within Europe, the European Society of Cardiology has led this movement with the Euro Heart Survey, a major program comprising registries to investigate clinical conditions such as acute coronary syndromes, heart failure, chronic stable angina, among others, as well as t...
Sex-related differences in ST-segment elevation myocardial infarction: A Portug...
Gonçalves, Carolina Miguel; Carvalho, Mariana; Vazão, Adriana; Cabral, Margarida; Martins, André; Saraiva, Fátima; Morais, JoãoIntroduction and objectives Sex differences among patients with acute myocardial infarctions remain a matter of debate. Inequalities in presentation, diagnosis, treatment, and prognosis are frequently observed, contributing to a worse prognosis in women. The aim of this study was to investigate sex-related differences in Portuguese ST-segment elevation myocardial infarction (STEMI) patients. Methods The authors...
European Journal of Heart Failure consensus statement. Heart failure pharmacoth...
Luedde, Mark; Agewall, Stefan; Ambrosio, Giuseppe; Bayes‐Genis, Antoni; Borghi, Claudio; Cerbai, Elisabetta; Dan, Gheorghe A.; Drexel, HeinzHeart failure (HF) and atrial fibrillation (AF) are major global health challenges with rising prevalence and significant morbidity, mortality, and healthcare burden. Despite advances in HF management, AF remains a critical comorbidity that worsens outcomes and requires ad hoc treatment strategies, increasing the risk of non-adherence and side effects. While rhythm control strategies in AF have gained attention...