21 documents found, page 1 of 3
Coagulação Intravascular Disseminada como Primeira Manifestação de Neoplasia da...
Eusébio, Sofia; Cunha, Sofia; Soares, Ana Raquel; Rodrigues, Afonso; Garcia, TeresaA coagulação intravascular disseminada (CID) pode ser definida como uma síndrome adquirida caracterizada por ativação excessiva e desregulada da cascata de coagulação, causada por formação de microtrombos e consumo de fatores de coagulação e plaquetas, resultando, em última análise, em disfunção multiorgânica. Tanto a sua forma aguda como a crónica podem estar associadas a hemorragia e/ou trombose. Os autores a...
Influenza A virus propagation requires the activation of the unfolded protein r...
Marques, Mariana; Ramos, Bruno; Albuquerque, Hélio; Pereira, Marisa; Ribeiro, Diana Roberta; Nunes, Alexandre; Sarabando, Jéssica; Brás, DanielaInfluenza A virus (IAV) employs multiple strategies to manipulate cellular mechanisms and support proper virion formation and propagation. In this study, we performed a detailed analysis of the interplay between IAV and the host cells’ proteostasis throughout the entire infectious cycle. We reveal that IAV infection activates the inositol requiring enzyme 1 (IRE1) branch of the unfolded protein response, and th...
Biofilm matrix regulation by Candida glabrata Zap1 under acidic conditions: tra...
Gonçalves, Bruna Fernandes; Pires, Diana Priscila Penso; Fernandes, L.; Pacheco, Miguel; Ferreira, Tiago; Osório, Hugo; Soares, Ana RaquelThe vaginal acidic environment potentiates the formation of Candida glabrata biofilms, leading to complicated and recurrent infections. Importantly, the production of matrix is known to contribute to the recalcitrant features of Candida biofilms. In this study, we reveal that Zap1 regulates the matrix of C. glabrata acidic biofilms and analyzed the modulation of their transcriptome (by microarrays) and matrix p...
Sfl1 is required for Candida albicans biofilm formation under acidic conditions
Gonçalves, Bruna Fernandes; Barbosa, Ana Teresa Moutinho; Soares, Ana Raquel; Henriques, Mariana; Silva, Sónia CarinaCandida albicans is a common Candida species, responsible for infections in various anatomical sites under different environmental conditions, aggravated in the presence of its biofilms. As such, this study aimed to reveal the regulation of C. albicans biofilms under acidic conditions by the transcription factor Sfl1, whose role on biofilm formation is unclear. For that, microbiologic and transcriptomic analyse...
Sfl1 is required for Candida albicans biofilm formation under acidic conditions
Gonçalves, Bruna; Barbosa, Ana; Soares, Ana Raquel; Henriques, Mariana; Silva, SóniaCandida albicans is a common Candida species, responsible for infections in various anatomical sites under different environmental conditions, aggravated in the presence of its biofilms. As such, this study aimed to reveal the regulation of C. albicans biofilms under acidic conditions by the transcription factor Sfl1, whose role on biofilm formation is unclear. For that, microbiologic and transcriptomic analyse...
The hidden RNA code: implications of the RNA epitranscriptome in the context of...
Ribeiro, Diana Roberta; Nunes, Alexandre; Ribeiro, Daniela; Soares, Ana RaquelEmerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms. Here, we discuss how specific RNA modifications, in either host or viral RNA molecules, impact the virus-life cycle and host antiviral responses, highlighting the potenti...
Steroid–quinoline hybrids for disruption and reversion of protein aggregation p...
Albuquerque, Hélio; Silva, Raquel Nunes da; Pereira, Marisa; Maia, André; Guieu, Samuel; Soares, Ana Raquel; Santos, Clementina M.M.; Vieira, Sandra I.Reversing protein aggregation within cells may be an important tool to fight protein-misfolding disorders such as Alzheimer’s, Parkinson’s, and cardiovascular diseases. Here we report the design and synthesis of a family of steroid−quinoline hybrid compounds based on the framework combination approach. This set of hybrid compounds effectively inhibited Aβ1−42 self-aggregation in vitro by delaying the exponentia...
The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Br...
Francisco, Stephany; Martinho, Vera C.; Ferreira, Margarida; Reis, Andreia; Moura, Gabriela; Soares, Ana Raquel; Santos, Manuel A. S.Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...
Steroid-quinoline hybrids for disruption and reversion of protein aggregation p...
Albuquerque, Hélio M. T.; Silva, Raquel Nunes da; Pereira, Marisa; Maia, André; Guieu, Samuel; Soares, Ana Raquel; Santos, Clementina M. M.Reversing protein aggregation within cells may be an important tool to fight protein-misfolding disorders such as Alzheimer's, Parkinson's, and cardiovascular diseases. Here we report the design and synthesis of a family of steroid-quinoline hybrid compounds based on the framework combination approach. This set of hybrid compounds effectively inhibited Aβ1-42 self-aggregation in vitro by delaying the exponentia...
The role of MicroRNAs in proteostasis decline and protein aggregation during br...
Francisco, Stephany; Martinho, Vera; Ferreira, Margarida; Reis, Andreia; Moura, Gabriela; Soares, Ana Raquel; Santos Manuel A. S.Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...